267058

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazF-pemI/MazF(toxin)
Location 243571..244207 Replicon chromosome
Accession NZ_CP115153
Organism Sutcliffiella sp. NC1

Toxin (Protein)


Gene name mazF Uniprot ID A0A223KXJ3
Locus tag O1A01_RS01295 Protein ID WP_066417781.1
Coordinates 243857..244207 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID A0A223KXF9
Locus tag O1A01_RS01290 Protein ID WP_066417778.1
Coordinates 243571..243852 (+) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
O1A01_RS01270 (O1A01_01270) 239761..240486 - 726 WP_270065404.1 rhomboid family intramembrane serine protease -
O1A01_RS01275 (O1A01_01275) 240561..240920 + 360 WP_066417765.1 holo-ACP synthase -
O1A01_RS01280 (O1A01_01280) 241083..242111 + 1029 WP_268874278.1 outer membrane lipoprotein carrier protein LolA -
O1A01_RS01285 (O1A01_01285) 242264..243424 + 1161 WP_270065405.1 alanine racemase -
O1A01_RS01290 (O1A01_01290) 243571..243852 + 282 WP_066417778.1 antitoxin endoai Antitoxin
O1A01_RS01295 (O1A01_01295) 243857..244207 + 351 WP_066417781.1 type II toxin-antitoxin system endoribonuclease NdoA Toxin
O1A01_RS01300 (O1A01_01300) 244501..245328 + 828 WP_270065406.1 STAS domain-containing protein -
O1A01_RS01305 (O1A01_01305) 245325..245681 + 357 WP_270065407.1 STAS domain-containing protein -
O1A01_RS01310 (O1A01_01310) 245686..246087 + 402 WP_270065408.1 anti-sigma regulatory factor -
O1A01_RS01315 (O1A01_01315) 246104..247108 + 1005 WP_270065409.1 PP2C family protein-serine/threonine phosphatase -
O1A01_RS01320 (O1A01_01320) 247218..247526 + 309 WP_270065410.1 STAS domain-containing protein -
O1A01_RS01325 (O1A01_01325) 247549..248025 + 477 WP_270065411.1 anti-sigma B factor RsbW -
O1A01_RS01330 (O1A01_01330) 248000..248785 + 786 WP_270065412.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-113)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 13048.07 Da        Isoelectric Point: 4.8891

>T267058 WP_066417781.1 NZ_CP115153:243857-244207 [Sutcliffiella sp. NC1]
MIVKRGDVYFADLSPVVGSEQGGVRPVLVIQNDIGNRFSPTIIVAAITAQIQKAKLPTHVEIDAKRYGFERDSVILLEQI
RTIDKQRLTDKITHLDEEMMDRVDEALQISLGLIDF

Download         Length: 351 bp

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10721.22 Da        Isoelectric Point: 7.0152

>AT267058 WP_066417778.1 NZ_CP115153:243571-243852 [Sutcliffiella sp. NC1]
VSESSATTEIMVRLPQNLVSELDGLVKQENGNRNELIYQATKMYLRERKKRQIRESMRRGYMEMAKINLNIASEAFLAEY
EAEHTVERLVSGG

Download         Length: 282 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A223KXJ3

Antitoxin

Source ID Structure
AlphaFold DB A0A223KXF9

References