Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 3184337..3185076 Replicon chromosome
Accession NZ_CP115150
Organism Enterobacter hormaechei subsp. xiangfangensis strain MDCL 3

Toxin (Protein)


Gene name tacT Uniprot ID A0A3L9PBP9
Locus tag MUY00_RS15260 Protein ID WP_003857133.1
Coordinates 3184591..3185076 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID A0A837FCR9
Locus tag MUY00_RS15255 Protein ID WP_003857131.1
Coordinates 3184337..3184603 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUY00_RS15235 (MUY00_15235) 3179813..3180799 + 987 WP_003857123.1 DUF979 domain-containing protein -
MUY00_RS15240 (MUY00_15240) 3180809..3181804 + 996 WP_003857125.1 DUF2891 domain-containing protein -
MUY00_RS15245 (MUY00_15245) 3181826..3183214 - 1389 WP_058657060.1 MFS transporter -
MUY00_RS15250 (MUY00_15250) 3183344..3184273 + 930 WP_022651200.1 LysR family transcriptional regulator -
MUY00_RS15255 (MUY00_15255) 3184337..3184603 + 267 WP_003857131.1 DUF1778 domain-containing protein Antitoxin
MUY00_RS15260 (MUY00_15260) 3184591..3185076 + 486 WP_003857133.1 GNAT family N-acetyltransferase Toxin
MUY00_RS15265 (MUY00_15265) 3185254..3185685 - 432 WP_234783248.1 hypothetical protein -
MUY00_RS15270 (MUY00_15270) 3185660..3185785 - 126 WP_265114096.1 hypothetical protein -
MUY00_RS15275 (MUY00_15275) 3185923..3186507 + 585 WP_058657062.1 GDP-mannose pyrophosphatase -
MUY00_RS15280 (MUY00_15280) 3186592..3187350 + 759 WP_058657064.1 trans-aconitate 2-methyltransferase -
MUY00_RS15285 (MUY00_15285) 3187357..3188547 - 1191 WP_023314158.1 cytochrome c biogenesis protein/redoxin -
MUY00_RS15290 (MUY00_15290) 3188683..3189978 - 1296 WP_032609216.1 ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(58-151)

Antitoxin

Vibrio phage ICP1, Orf50

(6-82)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17540.23 Da        Isoelectric Point: 9.9658

>T267054 WP_003857133.1 NZ_CP115150:3184591-3185076 [Enterobacter hormaechei subsp. xiangfangensis]
VGRVTAPEPLSSVHQLAEFVSGEAVLDEWLKQRGLKNQALGAARTFVVCKTGTKQVAGFYSLATGSVNHTQATGNLRRNM
PDPIPVIILARLAVDVSLRGNGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKAFYIHHGFKASQTQERTLFLRLP
Q

Download         Length: 486 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10090.50 Da        Isoelectric Point: 4.3837

>AT267054 WP_003857131.1 NZ_CP115150:3184337-3184603 [Enterobacter hormaechei subsp. xiangfangensis]
MKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACQAAENVILDRRVFNFNDEQYAEFIDMLDAPVADDPAIEKLL
ARKPQWDV

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3L9PBP9

Antitoxin

Source ID Structure
AlphaFold DB A0A837FCR9

References