Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA(toxin)
Location 2392616..2394399 Replicon chromosome
Accession NZ_CP115150
Organism Enterobacter hormaechei subsp. xiangfangensis strain MDCL 3

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag MUY00_RS11355 Protein ID WP_045331150.1
Coordinates 2393050..2394399 (-) Length 450 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A837FFV9
Locus tag MUY00_RS11350 Protein ID WP_003859317.1
Coordinates 2392616..2393053 (-) Length 146 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUY00_RS11330 (MUY00_11330) 2387635..2388657 + 1023 WP_003859324.1 HTH-type transcriptional regulator GalS -
MUY00_RS11335 (MUY00_11335) 2388953..2389951 + 999 WP_017383382.1 galactose/glucose ABC transporter substrate-binding protein MglB -
MUY00_RS11340 (MUY00_11340) 2390031..2391551 + 1521 WP_003859320.1 galactose/methyl galactoside ABC transporter ATP-binding protein MglA -
MUY00_RS11345 (MUY00_11345) 2391567..2392577 + 1011 WP_003859318.1 galactose/methyl galactoside ABC transporter permease MglC -
MUY00_RS11350 (MUY00_11350) 2392616..2393053 - 438 WP_003859317.1 helix-turn-helix transcriptional regulator Antitoxin
MUY00_RS11355 (MUY00_11355) 2393050..2394399 - 1350 WP_045331150.1 HipA domain-containing protein Toxin
MUY00_RS11360 (MUY00_11360) 2394534..2395244 - 711 WP_003859314.1 outer membrane permeability protein SanA -
MUY00_RS11365 (MUY00_11365) 2395372..2396256 - 885 WP_003859312.1 cytidine deaminase -
MUY00_RS11370 (MUY00_11370) 2396385..2397080 - 696 WP_003859310.1 CidB/LrgB family autolysis modulator -
MUY00_RS11375 (MUY00_11375) 2397077..2397472 - 396 WP_003859308.1 CidA/LrgA family protein -
MUY00_RS11380 (MUY00_11380) 2397641..2398576 + 936 WP_003859306.1 tRNA dihydrouridine(16) synthase DusC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(166-406)

Antitoxin

Cro/C1-type helix-turn-helix domain

(75-128)


Sequences

Toxin        


Download         Length: 450 a.a.        Molecular weight: 51140.83 Da        Isoelectric Point: 4.6112

>T267049 WP_045331150.1 NZ_CP115150:c2394399-2393050 [Enterobacter hormaechei subsp. xiangfangensis]
METLTVQAYLNETWTDIALIKYPGSEKNDWNITQLDYLTEYAINFLDYDDFHAVSVNHPVSLFFDDHGQPGWLRFIDDII
PAGASRRYWINALDISELPVGQQNFLLLKFGTMSPVGNLRIKESVPEWNKFASTKTFTVADVIDRAADFLDYAQERGAAA
GGATGAGGEAPKLLLRCSETDAIWIDTWQNEPDNRDRYYLVKYPRGNRTEVDCNILRAEFHYYHELNAMGFSTIPVETMR
LEEGSHYPSLWLPRFDIVRNEQDQLVRLGMESVYSLLQKAPGTLLDHETTLRALINKITSSHMVQQQGYQFDIPGFVTEW
VRRDLLNIIFGNSDNHGRNTAFVKAENQIMLSPVYDFAPMKADPEGIPRTLKWSLSCESGGDYNFNTIAQTLAEWIPPAT
LLDALHETAVQLIDLPERLAARGVPEQIMEMPAMGFRYIPDKLSRWGLL

Download         Length: 1350 bp

Antitoxin


Download         Length: 146 a.a.        Molecular weight: 16185.64 Da        Isoelectric Point: 10.5154

>AT267049 WP_003859317.1 NZ_CP115150:c2393053-2392616 [Enterobacter hormaechei subsp. xiangfangensis]
MKTPNEAESELLQTLAQVRSVNKKRHHDEAEEPDKPSVVKRQRVTQGLTRISTLDRQAVLHAAIRDILLGKITQGEALKR
LRVEVLGLKQDEYAKLVSVSRKTLSDVENNRGNYSADVINKIFKPFGLQTGLVPVSKSLIASLFS

Download         Length: 438 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A837FFV9

References