Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) ykfI-yfjZ/CbtA-CbeA
Location 1516706..1517385 Replicon chromosome
Accession NZ_CP115150
Organism Enterobacter hormaechei subsp. xiangfangensis strain MDCL 3

Toxin (Protein)


Gene name ykfI Uniprot ID A0A0C7K7A4
Locus tag MUY00_RS07270 Protein ID WP_020324801.1
Coordinates 1517044..1517385 (+) Length 114 a.a.

Antitoxin (Protein)


Gene name yfjZ Uniprot ID -
Locus tag MUY00_RS07265 Protein ID WP_274413776.1
Coordinates 1516706..1517023 (+) Length 106 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUY00_RS07240 (MUY00_07240) 1511920..1515072 + 3153 WP_274413882.1 AIDA repeat-containing protein -
MUY00_RS07245 (MUY00_07245) 1515165..1515404 + 240 WP_163190131.1 DUF905 domain-containing protein -
MUY00_RS07250 (MUY00_07250) 1515507..1515965 + 459 WP_163190129.1 antirestriction protein -
MUY00_RS07255 (MUY00_07255) 1515981..1516457 + 477 WP_020324797.1 RadC family protein -
MUY00_RS07260 (MUY00_07260) 1516466..1516693 + 228 WP_020324796.1 DUF987 domain-containing protein -
MUY00_RS07265 (MUY00_07265) 1516706..1517023 + 318 WP_274413776.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
MUY00_RS07270 (MUY00_07270) 1517044..1517385 + 342 WP_020324801.1 TA system toxin CbtA family protein Toxin
MUY00_RS07275 (MUY00_07275) 1517501..1518334 + 834 WP_020324805.1 DUF4942 domain-containing protein -
MUY00_RS07285 (MUY00_07285) 1518637..1519143 + 507 WP_022651878.1 G/U mismatch-specific DNA glycosylase -
MUY00_RS07290 (MUY00_07290) 1519245..1521089 - 1845 WP_006812010.1 RNA polymerase sigma factor RpoD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1488679..1518334 29655


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-111)

Antitoxin

Antitoxin CbeA

(5-103)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12818.91 Da        Isoelectric Point: 9.1484

>T267047 WP_020324801.1 NZ_CP115150:1517044-1517385 [Enterobacter hormaechei subsp. xiangfangensis]
MKTLPAIISRAAKPCLSPVAVWQMLLTRLLEKHYGLTLNDTPFCDETVIQEHIDAGITLADAVNFLVEKYGLVRIDRNGF
VWQEQSPYLRAVDILRARQATGLLRQSRNNAIR

Download         Length: 342 bp

Antitoxin


Download         Length: 106 a.a.        Molecular weight: 11923.52 Da        Isoelectric Point: 6.4644

>AT267047 WP_274413776.1 NZ_CP115150:1516706-1517023 [Enterobacter hormaechei subsp. xiangfangensis]
MSNITWGLQRDTTPRLGARLVQEGNQLHYLADRASITGKFSDAECRKLDETFPYFISQMESMLITGEMNPRHAHCVTLYH
NGFTCEADTLGSCGYVYIAVYPIQR

Download         Length: 318 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0C7K7A4

Antitoxin

Source ID Structure

References