Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumAB/COG3657-dnstrm_HI1420
Location 432194..432790 Replicon chromosome
Accession NZ_CP115150
Organism Enterobacter hormaechei subsp. xiangfangensis strain MDCL 3

Toxin (Protein)


Gene name PumA Uniprot ID A0A837F9W8
Locus tag MUY00_RS02160 Protein ID WP_023315213.1
Coordinates 432194..432496 (+) Length 101 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID -
Locus tag MUY00_RS02165 Protein ID WP_023315212.1
Coordinates 432503..432790 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUY00_RS02140 (MUY00_02140) 428413..429762 + 1350 WP_003860344.1 lysine-sensitive aspartokinase 3 -
MUY00_RS02145 (MUY00_02145) 429856..430800 + 945 WP_022650218.1 ketopantoate/pantoate/pantothenate transporter PanS -
MUY00_RS02150 (MUY00_02150) 430851..431123 + 273 WP_003860346.1 DUF3811 domain-containing protein -
MUY00_RS02155 (MUY00_02155) 431124..431996 - 873 WP_003860347.1 23S rRNA pseudouridine(2604) synthase RluF -
MUY00_RS02160 (MUY00_02160) 432194..432496 + 303 WP_023315213.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
MUY00_RS02165 (MUY00_02165) 432503..432790 + 288 WP_023315212.1 putative addiction module antidote protein Antitoxin
MUY00_RS02170 (MUY00_02170) 432787..434418 - 1632 WP_003860350.1 Na/Pi cotransporter family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(3-93)

Antitoxin

Uncharacterized protein HI1420

(3-90)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11427.21 Da        Isoelectric Point: 10.1042

>T267046 WP_023315213.1 NZ_CP115150:432194-432496 [Enterobacter hormaechei subsp. xiangfangensis]
MKEIVQTESFRRWEQNLKDRRAKTIIASRLFRLANGLAGDIRPVGEGISELRIHFGPGYRVYFKDQGNCIIVLLCGGDKS
SQARDILMAKMLSNVSQWQE

Download         Length: 303 bp

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10171.73 Da        Isoelectric Point: 7.0086

>AT267046 WP_023315212.1 NZ_CP115150:432503-432790 [Enterobacter hormaechei subsp. xiangfangensis]
MHKLTPYDPANALVDDEEIAVFMADALETGDSAYIAKALGVIARAKGMSTISLQTGLSREQLYRSFSDKGNPTLKTTLAV
MKALGLRLTIKPSGD

Download         Length: 288 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A837F9W8

Antitoxin

Source ID Structure

References