267042

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) spoIISABC/SpoIISA-SpoIISB
Location 1910818..1911734 Replicon chromosome
Accession NZ_CP114899
Organism Bacillus subtilis strain

Toxin (Protein)


Gene name spoIISA Uniprot ID O34853
Locus tag O6U12_RS10310 Protein ID WP_003244695.1
Coordinates 1910818..1911564 (+) Length 249 a.a.

Antitoxin (Protein)


Gene name spoIISB Uniprot ID G4EXD8
Locus tag O6U12_RS10315 Protein ID WP_003232646.1
Coordinates 1911564..1911734 (+) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
O6U12_RS10285 (O6U12_10285) 1905936..1906037 - 102 Protein_2025 hypothetical protein -
O6U12_RS10290 (O6U12_10290) 1906146..1907096 - 951 WP_014476561.1 ring-cleaving dioxygenase -
O6U12_RS10295 (O6U12_10295) 1907485..1908801 + 1317 WP_041333863.1 serine/threonine exchanger -
O6U12_RS10300 (O6U12_10300) 1909077..1909694 + 618 WP_003218470.1 DUF47 domain-containing protein -
O6U12_RS10305 (O6U12_10305) 1909707..1910708 + 1002 WP_014479569.1 inorganic phosphate transporter -
O6U12_RS10310 (O6U12_10310) 1910818..1911564 + 747 WP_003244695.1 toxin-antitoxin-antitoxin system toxin SpoIISA Toxin
O6U12_RS10315 (O6U12_10315) 1911564..1911734 + 171 WP_003232646.1 three component toxin-antitoxin-antitoxin system antitoxin SpoIISB Antitoxin
O6U12_RS10320 (O6U12_10320) 1911820..1911957 + 138 WP_003232648.1 three component toxin-antitoxin-antitoxin system antitoxin SpoIISC -
O6U12_RS10325 (O6U12_10325) 1911995..1912888 - 894 WP_014479567.1 N-acetylmuramoyl-L-alanine amidase -
O6U12_RS10330 (O6U12_10330) 1912901..1913164 - 264 WP_003232653.1 phage holin -
O6U12_RS10335 (O6U12_10335) 1913177..1913446 - 270 WP_003232655.1 hemolysin XhlA family protein -
O6U12_RS10340 (O6U12_10340) 1913499..1914337 - 839 Protein_2036 phage-like element PBSX protein XepA -
O6U12_RS10345 (O6U12_10345) 1914381..1914545 - 165 WP_087960875.1 XkdX family protein -
O6U12_RS10350 (O6U12_10350) 1914542..1914871 - 330 WP_003232660.1 XkdW family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SpoIISA, type II toxin-antitoxin system

(3-238)

Antitoxin

Antitoxin SpoIISB

(1-56)


Sequences

Toxin        


Download         Length: 249 a.a.        Molecular weight: 29061.50 Da        Isoelectric Point: 4.6191

>T267042 WP_003244695.1 NZ_CP114899:1910818-1911564 [Bacillus subtilis]
MVLFFQIMVWCIVAGLGLYVYATWRFEAKVKEKMSAIRKTWYLLFVLGAMVYWTYEPTSLFTHWERYLIVAVSFALIDAF
IFLSAYVKKLAGSELETDTREILEENNEMLHMYLNRLKTYQYLLKNEPIHVYYGSIDAYAEGIDKLLKTYADKMNLTASL
CHYSTQADKDRLTEHMDDPADVQTRLDRKDVYYDQYGKVVLIPFTIETQNYVIKLTSDSIVTEFDYLLFTSLTSIYDLVL
PIEEEGEG

Download         Length: 747 bp

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6654.72 Da        Isoelectric Point: 11.0203

>AT267042 WP_003232646.1 NZ_CP114899:1911564-1911734 [Bacillus subtilis]
MERAFQNRCEPRAAKPFKILKKRSTTSVASYQVSPHTARIFKENERLIDEYKRKKA

Download         Length: 171 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3O6Q

Antitoxin

Source ID Structure
PDB 3O6Q
AlphaFold DB G4EXD8

References