Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 3913460..3914055 Replicon chromosome
Accession NZ_CP114896
Organism Escherichia coli strain CM93

Toxin (Protein)


Gene name chpB Uniprot ID U9XNP6
Locus tag O6117_RS19075 Protein ID WP_000239577.1
Coordinates 3913705..3914055 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID U9Y2K1
Locus tag O6117_RS19070 Protein ID WP_001223208.1
Coordinates 3913460..3913711 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
O6117_RS19060 (3909125) 3909125..3912904 + 3780 WP_000060911.1 autotransporter assembly complex protein TamB -
O6117_RS19065 (3912907) 3912907..3913248 + 342 WP_001219160.1 gamma-glutamylcyclotransferase -
O6117_RS19070 (3913460) 3913460..3913711 + 252 WP_001223208.1 type II toxin-antitoxin system antitoxin ChpS Antitoxin
O6117_RS19075 (3913705) 3913705..3914055 + 351 WP_000239577.1 endoribonuclease toxin ChpB Toxin
O6117_RS19080 (3914135) 3914135..3914665 - 531 WP_000055075.1 inorganic diphosphatase -
O6117_RS19085 (3914975) 3914975..3915931 + 957 WP_000265913.1 galactofuranose ABC transporter substrate-binding protein YtfQ -
O6117_RS19090 (3916071) 3916071..3917573 + 1503 WP_000205805.1 sugar ABC transporter ATP-binding protein -
O6117_RS19095 (3917587) 3917587..3917718 + 132 Protein_3710 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-114)

Antitoxin

SpoVT-AbrB domain

(6-49)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12492.40 Da        Isoelectric Point: 5.5572

>T267036 WP_000239577.1 NZ_CP114896:3913705-3914055 [Escherichia coli]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVRMMDLHARLAKRIGLAADEVVEEALLRLQAVVE

Download         Length: 351 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9271.58 Da        Isoelectric Point: 4.4201

>AT267036 WP_001223208.1 NZ_CP114896:3913460-3913711 [Escherichia coli]
MRITIKRWGNSAGMVIPNIVMKELNLQPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNAAELSEQDVWGKSTPAGD
EIW

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U9XNP6

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LQ26

References