Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type V Classification (family/domain) ghoTS/ghoT-GhoS
Location 3817597..3818094 Replicon chromosome
Accession NZ_CP114896
Organism Escherichia coli strain CM93

Toxin (Protein)


Gene name ghoT Uniprot ID L4JJG6
Locus tag O6117_RS18580 Protein ID WP_001173343.1
Coordinates 3817921..3818094 (+) Length 58 a.a.

Antitoxin (Protein)


Gene name ghoS Uniprot ID L4JK92
Locus tag O6117_RS18575 Protein ID WP_000398619.1
Coordinates 3817597..3817893 (+) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
O6117_RS18555 (3814328) 3814328..3815047 - 720 WP_000611288.1 two-component system response regulator DcuR -
O6117_RS18560 (3815044) 3815044..3816675 - 1632 WP_001216477.1 sensor histidine kinase -
O6117_RS18565 (3816856) 3816856..3817086 + 231 WP_000371704.1 4Fe-4S mono-cluster protein YjdI -
O6117_RS18570 (3817098) 3817098..3817370 + 273 WP_000405651.1 GNAT family N-acetyltransferase -
O6117_RS18575 (3817597) 3817597..3817893 + 297 WP_000398619.1 type V toxin-antitoxin system endoribonuclease antitoxin GhoS Antitoxin
O6117_RS18580 (3817921) 3817921..3818094 + 174 WP_001173343.1 type V toxin-antitoxin system toxin GhoT Toxin
O6117_RS18585 (3818213) 3818213..3819730 - 1518 WP_001295074.1 lysine--tRNA ligase -
O6117_RS18590 (3819967) 3819967..3821424 - 1458 WP_000856829.1 dipeptide/tripeptide permease DtpC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin GhoT/OrtT

(4-57)

Antitoxin

Endoribonuclease antitoxin GhoS

(5-94)


Sequences

Toxin        


Download         Length: 58 a.a.        Molecular weight: 6555.06 Da        Isoelectric Point: 10.2288

>T267035 WP_001173343.1 NZ_CP114896:3817921-3818094 [Escherichia coli]
MALFSKILIFYVIGVNISFVIIWFISHEKTHIRLLSAFLVGITWPMSLPVALLFSLF

Download         Length: 174 bp

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11467.97 Da        Isoelectric Point: 4.1705

>AT267035 WP_000398619.1 NZ_CP114896:3817597-3817893 [Escherichia coli]
MEGKNKFNTYVVSFDYPSSYSSVFLRLRSLMYDMNFSSIVADEYGIPRQLNENSFAITTSLAASEIEDLIRLKCLDLPDI
DFDLNIMTVDDYFRQFYK

Download         Length: 297 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9QI41

Antitoxin

Source ID Structure
PDB 2LLZ
AlphaFold DB A0A7U9QBH6

References