Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 2498935..2499589 Replicon chromosome
Accession NZ_CP114896
Organism Escherichia coli strain CM93

Toxin (Protein)


Gene name cptA Uniprot ID S1EEB2
Locus tag O6117_RS12245 Protein ID WP_000244777.1
Coordinates 2498935..2499342 (-) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag O6117_RS12250 Protein ID WP_000354046.1
Coordinates 2499323..2499589 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
O6117_RS12225 (2494892) 2494892..2496625 - 1734 WP_000813200.1 single-stranded-DNA-specific exonuclease RecJ -
O6117_RS12230 (2496631) 2496631..2497341 - 711 WP_000715214.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
O6117_RS12235 (2497366) 2497366..2498262 - 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
O6117_RS12240 (2498374) 2498374..2498895 + 522 WP_001055874.1 flavodoxin FldB -
O6117_RS12245 (2498935) 2498935..2499342 - 408 WP_000244777.1 protein YgfX Toxin
O6117_RS12250 (2499323) 2499323..2499589 - 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
O6117_RS12255 (2499832) 2499832..2500812 + 981 WP_000886062.1 tRNA-modifying protein YgfZ -
O6117_RS12260 (2501008) 2501008..2501667 - 660 WP_000250274.1 hemolysin III family protein -
O6117_RS12265 (2501831) 2501831..2502142 - 312 WP_001182957.1 N(4)-acetylcytidine aminohydrolase -
O6117_RS12270 (2502187) 2502187..2503620 + 1434 WP_001336277.1 6-phospho-beta-glucosidase BglA -
O6117_RS12275 (2503677) 2503677..2504420 - 744 WP_000951964.1 SDR family oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16031.96 Da        Isoelectric Point: 11.5202

>T267031 WP_000244777.1 NZ_CP114896:c2499342-2498935 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDGGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT267031 WP_000354046.1 NZ_CP114896:c2499589-2499323 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9LFV7

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References