Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 1532774..1533605 Replicon chromosome
Accession NZ_CP114896
Organism Escherichia coli strain CM93

Toxin (Protein)


Gene name yeeV Uniprot ID S1P968
Locus tag O6117_RS07680 Protein ID WP_000854814.1
Coordinates 1533231..1533605 (+) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID P76364
Locus tag O6117_RS07675 Protein ID WP_001285584.1
Coordinates 1532774..1533142 (+) Length 123 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
O6117_RS07660 (1530441) 1530441..1531973 + 1533 WP_001350525.1 protein YeeR -
O6117_RS07665 (1531970) 1531970..1532416 + 447 WP_000187523.1 RadC family protein -
O6117_RS07670 (1532479) 1532479..1532700 + 222 WP_000692323.1 DUF987 domain-containing protein -
O6117_RS07675 (1532774) 1532774..1533142 + 369 WP_001285584.1 type IV toxin-antitoxin system cytoskeleton bundling-enhancing antitoxin CbeA Antitoxin
O6117_RS07680 (1533231) 1533231..1533605 + 375 WP_000854814.1 type IV toxin-antitoxin system cytoskeleton-binding toxin CbtA Toxin
O6117_RS07685 (1533602) 1533602..1533796 + 195 WP_000988600.1 DUF5983 family protein -
O6117_RS07690 (1533842) 1533842..1533922 + 81 Protein_1499 hypothetical protein -
O6117_RS07695 (1534211) 1534211..1534339 - 129 Protein_1500 transposase domain-containing protein -
O6117_RS07700 (1534459) 1534459..1534593 + 135 WP_001297944.1 EutP/PduV family microcompartment system protein -
O6117_RS07705 (1534694) 1534694..1535023 - 330 WP_000450409.1 DUF496 family protein -
O6117_RS07710 (1535195) 1535195..1536253 - 1059 WP_001200891.1 FUSC family protein -
O6117_RS07715 (1536451) 1536451..1536924 - 474 WP_001105415.1 DNA gyrase inhibitor SbmC -
O6117_RS07720 (1537043) 1537043..1538209 - 1167 WP_000830156.1 serine-type D-Ala-D-Ala carboxypeptidase DacD -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(1-112)

Antitoxin

(18-117)


Sequences


Toxin        


Download         Length: 125 a.a.        Molecular weight: 13898.94 Da        Isoelectric Point: 7.8522

>T267026 WP_000854814.1 NZ_CP114896:1533231-1533605 [Escherichia coli]
MKTLPVLPGQAASSRPSPVEIWQILLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYPEAK

Download         Length: 375 bp


Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13651.52 Da        Isoelectric Point: 5.9541

>AT267026 WP_001285584.1 NZ_CP114896:1532774-1533142 [Escherichia coli]
VSDTLPGTTLPDDNHDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGLFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCKADTLSSCDYVYLAVYPTPEMKN

Download         Length: 369 bp


Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A829FY50


Antitoxin

Source ID Structure
PDB 2H28
AlphaFold DB A0A1M2E8G6

References