267010

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yfjZ-ypjF/CbtA-CbeA
Location 3418301..3418968 Replicon chromosome
Accession NZ_CP114895
Organism Escherichia coli strain CM56

Toxin (Protein)


Gene name ypjF Uniprot ID Q46953
Locus tag O6106_RS16825 Protein ID WP_001094400.1
Coordinates 3418639..3418968 (+) Length 110 a.a.

Antitoxin (Protein)


Gene name yfjZ Uniprot ID P52141
Locus tag O6106_RS16820 Protein ID WP_000072690.1
Coordinates 3418301..3418618 (+) Length 106 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
O6106_RS16790 (3413353) 3413353..3414362 - 1010 Protein_3260 arsenic transporter -
O6106_RS16795 (3414504) 3414504..3416207 + 1704 WP_000896263.1 protein YfjW -
O6106_RS16800 (3416818) 3416818..3417002 + 185 Protein_3262 DUF905 family protein -
O6106_RS16805 (3417105) 3417105..3417563 + 459 WP_000211841.1 antirestriction protein -
O6106_RS16810 (3417572) 3417572..3418054 + 483 WP_001407480.1 RadC family protein -
O6106_RS16815 (3418063) 3418063..3418263 + 201 WP_001395452.1 DUF987 domain-containing protein -
O6106_RS16820 (3418301) 3418301..3418618 + 318 WP_000072690.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
O6106_RS16825 (3418639) 3418639..3418968 + 330 WP_001094400.1 type IV toxin-antitoxin system toxin YpjF Toxin
O6106_RS16830 (3419332) 3419332..3423912 - 4581 WP_010723187.1 adhesin-like autotransporter YpjA/EhaD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-108)

Antitoxin

Antitoxin CbeA

(5-104)


Sequences

Toxin        


Download         Length: 110 a.a.        Molecular weight: 12308.21 Da        Isoelectric Point: 7.2761

>T267010 WP_001094400.1 NZ_CP114895:3418639-3418968 [Escherichia coli]
MNTLPATISQAAKPCLSPVAVWQMLLTRLLEQHYGLTLNDTPFSDETVIKEHIDAGITLADAVNFLVEKYELVRIDHRGF
SWQQQSPYISVVDILRARRSTGLLKTNVK

Download         Length: 330 bp

Antitoxin


Download         Length: 106 a.a.        Molecular weight: 11737.27 Da        Isoelectric Point: 6.4630

>AT267010 WP_000072690.1 NZ_CP114895:3418301-3418618 [Escherichia coli]
MSNTTWGLQRDITPRLGARLVQEGNQLHYLADRASITGKFSDAECPKLDVVFPHFISQIESMLTTGELNPRHAQCVTLYH
NGFTCEADTLGSCGYVYIAVYPTQR

Download         Length: 318 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A373F4I3

Antitoxin

Source ID Structure
PDB 2EA9
PDB 2JN7
AlphaFold DB P52141

References