266995

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yafW-ykfI/CbtA-CbeA
Location 902577..903256 Replicon chromosome
Accession NZ_CP114895
Organism Escherichia coli strain CM56

Toxin (Protein)


Gene name ykfI Uniprot ID P77692
Locus tag O6106_RS04345 Protein ID WP_000854672.1
Coordinates 902577..902918 (-) Length 114 a.a.

Antitoxin (Protein)


Gene name yafW Uniprot ID Q47684
Locus tag O6106_RS04350 Protein ID WP_000070395.1
Coordinates 902939..903256 (-) Length 106 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
O6106_RS04320 (897854) 897854..898255 + 402 WP_000174689.1 sigma factor-binding protein Crl -
O6106_RS04325 (898294) 898294..899349 - 1056 WP_000749863.1 phosphoporin PhoE -
O6106_RS04330 (899637) 899637..900740 + 1104 WP_001285288.1 glutamate 5-kinase -
O6106_RS04335 (900752) 900752..902005 + 1254 WP_000893278.1 glutamate-5-semialdehyde dehydrogenase -
O6106_RS04345 (902577) 902577..902918 - 342 WP_000854672.1 type IV toxin-antitoxin system toxin YkfI Toxin
O6106_RS04350 (902939) 902939..903256 - 318 WP_000070395.1 type IV toxin-antitoxin system antitoxin YafW Antitoxin
O6106_RS04355 (903275) 903275..903496 - 222 WP_000691994.1 DUF987 domain-containing protein -
O6106_RS04360 (903505) 903505..903981 - 477 WP_000811693.1 RadC family protein -
O6106_RS04365 (903997) 903997..904455 - 459 WP_000211838.1 antirestriction protein -
O6106_RS04370 (904553) 904553..904792 - 240 WP_000194654.1 DUF905 family protein -
O6106_RS04375 (904869) 904869..905336 - 468 WP_001547765.1 protein YkfB -
O6106_RS04380 (905359) 905359..905802 - 444 WP_269707801.1 lipoprotein YafY -
O6106_RS04385 (905802) 905802..906029 - 228 WP_001548158.1 protein YpjK -
O6106_RS04390 (906025) 906025..906216 - 192 Protein_834 DeoR family transcriptional regulator -
O6106_RS04395 (906433) 906433..907254 - 822 WP_000197389.1 DUF932 domain-containing protein -
O6106_RS04400 (907346) 907346..908209 - 864 WP_001065553.1 GTPase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(6-104)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12905.01 Da        Isoelectric Point: 9.6543

>T266995 WP_000854672.1 NZ_CP114895:c902918-902577 [Escherichia coli]
MKTLPAITQRAVKPCLSPVAVWQMLLTRLLEQHYGLTINDTPFCNEAVIKEHIDAGITLADAVNFLVEKYELVRIDRKGF
SWQEQSPYLRAADILRARQATGLLRQSRNNVVR

Download         Length: 342 bp

Antitoxin


Download         Length: 106 a.a.        Molecular weight: 11939.59 Da        Isoelectric Point: 6.7391

>AT266995 WP_000070395.1 NZ_CP114895:c903256-902939 [Escherichia coli]
MSNPTRGLQREITLRLGARLVQEGNRLHYLADRASITGKFSDIECRKLDETFPHFILQMESMLTTGELSPHHAHCVTLYH
NDLTCEADTLGSCGYVYIAIYPTQR

Download         Length: 318 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB P77692

Antitoxin

Source ID Structure
AlphaFold DB Q47684

References