266991

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 525278..525873 Replicon chromosome
Accession NZ_CP114895
Organism Escherichia coli strain CM56

Toxin (Protein)


Gene name chpB Uniprot ID U9XNP6
Locus tag O6106_RS02480 Protein ID WP_000239577.1
Coordinates 525523..525873 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID U9Y2K1
Locus tag O6106_RS02475 Protein ID WP_001223208.1
Coordinates 525278..525529 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
O6106_RS02465 (520943) 520943..524722 + 3780 WP_000060911.1 autotransporter assembly complex protein TamB -
O6106_RS02470 (524725) 524725..525066 + 342 WP_001219160.1 gamma-glutamylcyclotransferase -
O6106_RS02475 (525278) 525278..525529 + 252 WP_001223208.1 type II toxin-antitoxin system antitoxin ChpS Antitoxin
O6106_RS02480 (525523) 525523..525873 + 351 WP_000239577.1 endoribonuclease toxin ChpB Toxin
O6106_RS02485 (525953) 525953..526483 - 531 WP_000055075.1 inorganic diphosphatase -
O6106_RS02490 (526793) 526793..527749 + 957 WP_000265913.1 galactofuranose ABC transporter substrate-binding protein YtfQ -
O6106_RS02495 (527889) 527889..529391 + 1503 WP_000205805.1 sugar ABC transporter ATP-binding protein -
O6106_RS02500 (529405) 529405..529536 + 132 Protein_468 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-114)

Antitoxin

SpoVT-AbrB domain

(6-49)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12492.40 Da        Isoelectric Point: 5.5572

>T266991 WP_000239577.1 NZ_CP114895:525523-525873 [Escherichia coli]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVRMMDLHARLAKRIGLAADEVVEEALLRLQAVVE

Download         Length: 351 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9271.58 Da        Isoelectric Point: 4.4201

>AT266991 WP_001223208.1 NZ_CP114895:525278-525529 [Escherichia coli]
MRITIKRWGNSAGMVIPNIVMKELNLQPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNAAELSEQDVWGKSTPAGD
EIW

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U9XNP6

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LQ26

References