Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4375331..4375949 Replicon chromosome
Accession NZ_CP114894
Organism Escherichia coli strain CM19

Toxin (Protein)


Gene name Hha Uniprot ID -
Locus tag O6X69_RS21460 Protein ID WP_001290581.1
Coordinates 4375331..4375549 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag O6X69_RS21465 Protein ID WP_000344800.1
Coordinates 4375575..4375949 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
O6X69_RS21425 (4370620) 4370620..4371192 + 573 WP_000779842.1 YbaY family lipoprotein -
O6X69_RS21430 (4371223) 4371223..4371534 - 312 WP_000409911.1 MGMT family protein -
O6X69_RS21440 (4371913) 4371913..4372266 + 354 WP_000878140.1 DUF1428 domain-containing protein -
O6X69_RS21445 (4372308) 4372308..4373858 - 1551 WP_001310610.1 cyclic-guanylate-specific phosphodiesterase PdeB -
O6X69_RS21450 (4374022) 4374022..4374492 - 471 WP_000136192.1 YlaC family protein -
O6X69_RS21455 (4374608) 4374608..4375159 - 552 WP_000102564.1 maltose O-acetyltransferase -
O6X69_RS21460 (4375331) 4375331..4375549 - 219 WP_001290581.1 HHA domain-containing protein Toxin
O6X69_RS21465 (4375575) 4375575..4375949 - 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
O6X69_RS21470 (4376495) 4376495..4379644 - 3150 WP_001132469.1 efflux RND transporter permease AcrB -
O6X69_RS21475 (4379667) 4379667..4380860 - 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8678.06 Da        Isoelectric Point: 8.9008

>T266989 WP_001290581.1 NZ_CP114894:c4375549-4375331 [Escherichia coli]
MSEKFLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT266989 WP_000344800.1 NZ_CP114894:c4375949-4375575 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References