Detailed information of TA system TA026698

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): TscAT/-
• Location: 910252..910784
• Replicon: chromosome
• Accession: NC_017347
• Organism: Staphylococcus aureus subsp. aureus T0131

Toxin (Protein)

• Gene name: TscT
• Uniprot ID: Q93CD4
• Locus tag: SAT0131_RS04520
• Protein ID: WP_001103942.1
• Coordinates: 910464..910784 (+)
• Length: 107 a.a.

Antitoxin (Protein)

• Gene name: TscA
• Uniprot ID: -
• Locus tag: SAT0131_RS04515
• Protein ID: WP_001058486.1
• Coordinates: 910252..910461 (+)
• Length: 70 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SAT0131_RS04470	905272..906492	-	1221	WP_000264182.1	site-specific integrase	-
SAT0131_RS04475	906580..907308	-	729	WP_000733773.1	staphylococcal enterotoxin type K	-
SAT0131_RS04480	907332..908060	-	729	WP_001033319.1	staphylococcal enterotoxin type Q	-
SAT0131_RS04485	908130..908561	-	432	WP_001228758.1	hypothetical protein	-
SAT0131_RS04490	908578..909036	-	459	WP_000281657.1	ImmA/IrrE family metallo-endopeptidase	-
SAT0131_RS04495	909048..909380	-	333	WP_001260004.1	helix-turn-helix transcriptional regulator	-
SAT0131_RS04500	909573..909836	+	264	WP_000243851.1	helix-turn-helix domain-containing protein	-
SAT0131_RS04505	909829..910101	+	273	WP_000091731.1	helix-turn-helix domain-containing protein	-
SAT0131_RS04510	910113..910259	+	147	WP_000784875.1	hypothetical protein	-
SAT0131_RS04515	910252..910461	+	210	WP_001058486.1	hypothetical protein	Antitoxin
SAT0131_RS04520	910464..910784	+	321	WP_001103942.1	DUF1474 family protein	Toxin
SAT0131_RS04525	910848..911718	+	871	Protein_871	primase alpha helix C-terminal domain-containing protein	-
SAT0131_RS04530	911732..913441	+	1710	WP_000447445.1	DUF927 domain-containing protein	-
SAT0131_RS04535	913752..914132	+	381	WP_000356943.1	hypothetical protein	-
SAT0131_RS04540	914129..914770	+	642	WP_001019597.1	hypothetical protein	-
SAT0131_RS04545	915306..915647	+	342	WP_001190605.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	selk / selq	887379..917821	30442

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF1474 (1-98)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 107 a.a.
• Molecular weight: 12694.22 Da
• Isoelectric Point: 4.7419

>T26698 WP_001103942.1 NC_017347:910464-910784 [Staphylococcus aureus subsp. aureus T0131]
MNWEIKDLMCDIEVIKQKINDVATKHAWFVEDRFVKNELETKREHINFSASYLEHRIQNEHTVELLHVYLKEFSELIQKF
HEIEKASSENFDEESDDAKNSIKVAE

Nucleotide

• Length: 321 bp

>T26698 NC_017347:910464-910784 [Staphylococcus aureus subsp. aureus T0131]
ATGAATTGGGAAATTAAAGATTTAATGTGTGACATTGAAGTGATAAAACAAAAAATTAATGATGTAGCTACCAAACATGC
TTGGTTTGTTGAAGATAGATTTGTAAAAAATGAATTAGAAACAAAACGGGAACATATTAATTTTTCTGCTAGCTATTTAG
AACATCGTATACAAAATGAACATACAGTTGAGTTATTACATGTGTACTTAAAAGAATTCAGTGAACTTATACAAAAATTT
CATGAAATAGAAAAAGCGTCATCAGAGAACTTTGACGAGGAATCAGATGACGCAAAGAATTCAATAAAAGTAGCAGAGTA
A

Antitoxin

Protein

• Length: 70 a.a.
• Molecular weight: 8252.31 Da
• Isoelectric Point: 4.3718

>AT26698 WP_001058486.1 NC_017347:910252-910461 [Staphylococcus aureus subsp. aureus T0131]
MNNEQKEVIEHLVYQLELSVMNNLESYEHTEYVNGIEVVSEISREKHLELIMKWCAQELKNNFQLEKGE

Nucleotide

• Length: 210 bp

>AT26698 NC_017347:910252-910461 [Staphylococcus aureus subsp. aureus T0131]
ATGAATAATGAACAAAAAGAAGTAATAGAACACTTGGTTTATCAACTTGAGTTAAGTGTCATGAATAATTTGGAAAGTTA
CGAACACACAGAATATGTTAATGGTATTGAAGTGGTTTCAGAGATCAGTCGTGAAAAGCACTTAGAATTGATAATGAAAT
GGTGCGCACAAGAATTAAAGAATAATTTTCAATTAGAGAAAGGAGAATAA

Structures

Toxin

• AlphaFold DB: Q93CD4