Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 2399486..2400140 Replicon chromosome
Accession NZ_CP114894
Organism Escherichia coli strain CM19

Toxin (Protein)


Gene name cptA Uniprot ID S1EEB2
Locus tag O6X69_RS11790 Protein ID WP_000244777.1
Coordinates 2399486..2399893 (-) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag O6X69_RS11795 Protein ID WP_000354046.1
Coordinates 2399874..2400140 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
O6X69_RS11770 (2395443) 2395443..2397176 - 1734 WP_000813200.1 single-stranded-DNA-specific exonuclease RecJ -
O6X69_RS11775 (2397182) 2397182..2397892 - 711 WP_000715214.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
O6X69_RS11780 (2397917) 2397917..2398813 - 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
O6X69_RS11785 (2398925) 2398925..2399446 + 522 WP_001055874.1 flavodoxin FldB -
O6X69_RS11790 (2399486) 2399486..2399893 - 408 WP_000244777.1 protein YgfX Toxin
O6X69_RS11795 (2399874) 2399874..2400140 - 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
O6X69_RS11800 (2400383) 2400383..2401363 + 981 WP_000886062.1 tRNA-modifying protein YgfZ -
O6X69_RS11805 (2401559) 2401559..2402218 - 660 WP_000250274.1 hemolysin III family protein -
O6X69_RS11810 (2402382) 2402382..2402693 - 312 WP_001182957.1 N(4)-acetylcytidine aminohydrolase -
O6X69_RS11815 (2402738) 2402738..2404171 + 1434 WP_001336277.1 6-phospho-beta-glucosidase BglA -
O6X69_RS11820 (2404228) 2404228..2404971 - 744 WP_000951964.1 SDR family oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16031.96 Da        Isoelectric Point: 11.5202

>T266979 WP_000244777.1 NZ_CP114894:c2399893-2399486 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDGGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT266979 WP_000354046.1 NZ_CP114894:c2400140-2399874 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9LFV7

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References