Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yfjZ-ypjF/CbtA-CbeA
Location 2129532..2130199 Replicon chromosome
Accession NZ_CP114894
Organism Escherichia coli strain CM19

Toxin (Protein)


Gene name ypjF Uniprot ID Q46953
Locus tag O6X69_RS10525 Protein ID WP_001094400.1
Coordinates 2129870..2130199 (+) Length 110 a.a.

Antitoxin (Protein)


Gene name yfjZ Uniprot ID P52141
Locus tag O6X69_RS10520 Protein ID WP_000072690.1
Coordinates 2129532..2129849 (+) Length 106 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
O6X69_RS10490 (2124584) 2124584..2125593 - 1010 Protein_2045 arsenic transporter -
O6X69_RS10495 (2125735) 2125735..2127438 + 1704 WP_000896263.1 protein YfjW -
O6X69_RS10500 (2128049) 2128049..2128233 + 185 Protein_2047 DUF905 family protein -
O6X69_RS10505 (2128336) 2128336..2128794 + 459 WP_000211841.1 antirestriction protein -
O6X69_RS10510 (2128803) 2128803..2129285 + 483 WP_001407480.1 RadC family protein -
O6X69_RS10515 (2129294) 2129294..2129494 + 201 WP_001395452.1 DUF987 domain-containing protein -
O6X69_RS10520 (2129532) 2129532..2129849 + 318 WP_000072690.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
O6X69_RS10525 (2129870) 2129870..2130199 + 330 WP_001094400.1 type IV toxin-antitoxin system toxin YpjF Toxin
O6X69_RS10530 (2130563) 2130563..2135143 - 4581 WP_010723187.1 adhesin-like autotransporter YpjA/EhaD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2108576..2155009 46433


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-108)

Antitoxin

Antitoxin CbeA

(5-104)


Sequences

Toxin        


Download         Length: 110 a.a.        Molecular weight: 12308.21 Da        Isoelectric Point: 7.2761

>T266977 WP_001094400.1 NZ_CP114894:2129870-2130199 [Escherichia coli]
MNTLPATISQAAKPCLSPVAVWQMLLTRLLEQHYGLTLNDTPFSDETVIKEHIDAGITLADAVNFLVEKYELVRIDHRGF
SWQQQSPYISVVDILRARRSTGLLKTNVK

Download         Length: 330 bp

Antitoxin


Download         Length: 106 a.a.        Molecular weight: 11737.27 Da        Isoelectric Point: 6.4630

>AT266977 WP_000072690.1 NZ_CP114894:2129532-2129849 [Escherichia coli]
MSNTTWGLQRDITPRLGARLVQEGNQLHYLADRASITGKFSDAECPKLDVVFPHFISQIESMLTTGELNPRHAQCVTLYH
NGFTCEADTLGSCGYVYIAVYPTQR

Download         Length: 318 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A373F4I3

Antitoxin

Source ID Structure
PDB 2EA9
PDB 2JN7
AlphaFold DB P52141

References