Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | rnlAB/RnlA-RnlB |
Location | 2118335..2119772 | Replicon | chromosome |
Accession | NZ_CP114894 | ||
Organism | Escherichia coli strain CM19 |
Toxin (Protein)
Gene name | rnlA | Uniprot ID | P52129 |
Locus tag | O6X69_RS10445 | Protein ID | WP_000155570.1 |
Coordinates | 2118335..2119408 (+) | Length | 358 a.a. |
Antitoxin (Protein)
Gene name | rnlB | Uniprot ID | P52130 |
Locus tag | O6X69_RS10450 | Protein ID | WP_000461704.1 |
Coordinates | 2119401..2119772 (+) | Length | 124 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
O6X69_RS10430 (2113768) | 2113768..2115957 | - | 2190 | WP_000136402.1 | DEAD/DEAH box helicase | - |
O6X69_RS10435 (2115954) | 2115954..2117570 | - | 1617 | WP_000445380.1 | anti-bacteriophage protein AbpA | - |
O6X69_RS10440 (2117930) | 2117930..2118193 | - | 264 | WP_000502050.1 | DUF1524 domain-containing protein | - |
O6X69_RS10445 (2118335) | 2118335..2119408 | + | 1074 | WP_000155570.1 | type II toxin-antitoxin system toxin mRNA endoribonuclease RnlA | Toxin |
O6X69_RS10450 (2119401) | 2119401..2119772 | + | 372 | WP_000461704.1 | type II toxin-antitoxin system antitoxin RnlB | Antitoxin |
O6X69_RS10455 (2120127) | 2120127..2120990 | + | 864 | WP_000787597.1 | GTPase family protein | - |
O6X69_RS10460 (2121082) | 2121082..2121903 | + | 822 | WP_000197391.1 | DUF932 domain-containing protein | - |
O6X69_RS10465 (2122120) | 2122120..2122821 | + | 702 | WP_000189409.1 | WYL domain-containing protein | - |
O6X69_RS10470 (2122862) | 2122862..2123098 | + | 237 | WP_001144029.1 | protein YpjK | - |
O6X69_RS10475 (2123098) | 2123098..2123541 | + | 444 | WP_000824222.1 | lipoprotein YfjS | - |
O6X69_RS10480 (2123565) | 2123565..2124032 | + | 468 | WP_000702495.1 | protein YfjT | - |
O6X69_RS10485 (2124419) | 2124419..2124571 | - | 153 | Protein_2044 | arsenate reductase | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Genomic island | - | - | 2108576..2155009 | 46433 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 358 a.a. Molecular weight: 40061.13 Da Isoelectric Point: 6.8293
>T266976 WP_000155570.1 NZ_CP114894:2118335-2119408 [Escherichia coli]
MTIRSYKNLNLVRANIETESRQFIENKNYSIQSIGPMPGSRAGLRVVFTRPGVNLATVDIFYNGDGSTTIQYLTGANRSL
GQELADHLFETINPAEFEQVNMVLQGFVETSVLPVLELSADESHIEFREHSRNAHTVVWKIISTSYQDELTVSLHITTGK
LQIQGRPLSCYRVFTFNLAALLDLQGLEKVLIRQEDGKANIVQQEVARTYLQTVMADAYPHLHVTAEKLLVSGLCVKLAA
PDLPDYCMLLYPELRTIEGVLKSKMSGLGMPVQQPAGFGTYFDKPAAHYILKPQFAATLRPEQINIISTAYTFFNVERHS
LFHMETVVDASRMISDMARLMGKATRAWGIIKDLYIV
MTIRSYKNLNLVRANIETESRQFIENKNYSIQSIGPMPGSRAGLRVVFTRPGVNLATVDIFYNGDGSTTIQYLTGANRSL
GQELADHLFETINPAEFEQVNMVLQGFVETSVLPVLELSADESHIEFREHSRNAHTVVWKIISTSYQDELTVSLHITTGK
LQIQGRPLSCYRVFTFNLAALLDLQGLEKVLIRQEDGKANIVQQEVARTYLQTVMADAYPHLHVTAEKLLVSGLCVKLAA
PDLPDYCMLLYPELRTIEGVLKSKMSGLGMPVQQPAGFGTYFDKPAAHYILKPQFAATLRPEQINIISTAYTFFNVERHS
LFHMETVVDASRMISDMARLMGKATRAWGIIKDLYIV
Download Length: 1074 bp
Antitoxin
Download Length: 124 a.a. Molecular weight: 13664.69 Da Isoelectric Point: 4.2391
>AT266976 WP_000461704.1 NZ_CP114894:2119401-2119772 [Escherichia coli]
MFEITGINVSGALKAVVMATGFENPLSSVNEIETKLSALLGSETTGEILFDLLCANGPEWNRFVTLEMKYGRIMLDTAKI
IDEQDVPTHILSKLTFTLRNHPEYLEASVLSPDDVRQVLSMDF
MFEITGINVSGALKAVVMATGFENPLSSVNEIETKLSALLGSETTGEILFDLLCANGPEWNRFVTLEMKYGRIMLDTAKI
IDEQDVPTHILSKLTFTLRNHPEYLEASVLSPDDVRQVLSMDF
Download Length: 372 bp
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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