26697

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 892695..893172 Replicon chromosome
Accession NC_017347
Organism Staphylococcus aureus subsp. aureus T0131

Toxin (Protein)


Gene name TsaT Uniprot ID Q2G005
Locus tag SAT0131_RS04370 Protein ID WP_000052078.1
Coordinates 892695..892883 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag SAT0131_RS04375 Protein ID WP_001059690.1
Coordinates 892912..893172 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SAT0131_RS04340 888736..889206 + 471 WP_000824472.1 hypothetical protein -
SAT0131_RS04345 889547..890233 + 687 WP_001548082.1 thermonuclease family protein -
SAT0131_RS04350 890590..890790 + 201 WP_001059082.1 cold-shock protein -
SAT0131_RS04355 891286..891504 - 219 WP_000005886.1 hypothetical protein -
SAT0131_RS04360 891566..891850 - 285 WP_001004395.1 hypothetical protein -
SAT0131_RS04365 891938..892507 - 570 WP_001106644.1 hypothetical protein -
SAT0131_RS04370 892695..892883 - 189 WP_000052078.1 hypothetical protein Toxin
SAT0131_RS04375 892912..893172 - 261 WP_001059690.1 hypothetical protein Antitoxin
SAT0131_RS04380 893513..893716 + 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
SAT0131_RS04385 893713..893949 - 237 WP_000368687.1 hypothetical protein -
SAT0131_RS04390 894174..894755 + 582 WP_001140685.1 phosphoglycerate mutase family protein -
SAT0131_RS04395 894828..895445 - 618 WP_000255561.1 LysE/ArgO family amino acid transporter -
SAT0131_RS04400 895600..896094 - 495 WP_000569884.1 GNAT family N-acetyltransferase -
SAT0131_RS04405 896492..896914 - 423 WP_000974460.1 organic hydroperoxide resistance protein -
SAT0131_RS04410 897062..897778 + 717 WP_000150017.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - selk / selq 887379..917821 30442


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-100)

Antitoxin

Post-segregation antitoxin CcdA

(2-72)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7172.84 Da        Isoelectric Point: 9.9971

>T26697 WP_000052078.1 NC_017347:c892883-892695 [Staphylococcus aureus subsp. aureus T0131]
MSLHFAILFWLALIFLVAATFILVLMKKTSKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T26697 NC_017347:c892883-892695 [Staphylococcus aureus subsp. aureus T0131]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTAGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT26697 WP_001059690.1 NC_017347:c893172-892912 [Staphylococcus aureus subsp. aureus T0131]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT26697 NC_017347:c893172-892912 [Staphylococcus aureus subsp. aureus T0131]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0D6HZ40

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References