Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 3605928..3606566 Replicon chromosome
Accession NZ_CP114893
Organism Escherichia coli strain CM13

Toxin (Protein)


Gene name hicA Uniprot ID S1F9G9
Locus tag O6R07_RS17620 Protein ID WP_000813794.1
Coordinates 3606390..3606566 (-) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag O6R07_RS17615 Protein ID WP_001270286.1
Coordinates 3605928..3606344 (-) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
O6R07_RS17595 (3601080) 3601080..3602021 - 942 WP_001251304.1 ABC transporter permease -
O6R07_RS17600 (3602022) 3602022..3603035 - 1014 WP_000220396.1 ABC transporter ATP-binding protein -
O6R07_RS17605 (3603053) 3603053..3604198 - 1146 WP_000047424.1 ABC transporter substrate-binding protein -
O6R07_RS17610 (3604443) 3604443..3605849 - 1407 WP_000760626.1 PLP-dependent aminotransferase family protein -
O6R07_RS17615 (3605928) 3605928..3606344 - 417 WP_001270286.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
O6R07_RS17620 (3606390) 3606390..3606566 - 177 WP_000813794.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
O6R07_RS17625 (3606788) 3606788..3607018 + 231 WP_000494244.1 YncJ family protein -
O6R07_RS17630 (3607110) 3607110..3609071 - 1962 WP_001303492.1 23S rRNA 5-hydroxycytidine C2501 synthase -
O6R07_RS17635 (3609144) 3609144..3609680 - 537 WP_000429155.1 DNA-binding transcriptional regulator SutR -
O6R07_RS17640 (3609733) 3609733..3610947 + 1215 WP_001326689.1 BenE family transporter YdcO -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

Cro/C1-type helix-turn-helix domain

(91-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6749.83 Da        Isoelectric Point: 11.2298

>T266963 WP_000813794.1 NZ_CP114893:c3606566-3606390 [Escherichia coli]
VKQSEFRRWLESQGVDVANGSNHLKLRFHGRRSVMPRHPCDEIKEPLRKAILKQLGLS

Download         Length: 177 bp

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15246.63 Da        Isoelectric Point: 4.7386

>AT266963 WP_001270286.1 NZ_CP114893:c3606344-3605928 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6HPB

Antitoxin

Source ID Structure

References