266947

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type V Classification (family/domain) ghoTS/ghoT-GhoS
Location 749158..749655 Replicon chromosome
Accession NZ_CP114893
Organism Escherichia coli strain CM13

Toxin (Protein)


Gene name ghoT Uniprot ID L4JJG6
Locus tag O6R07_RS03795 Protein ID WP_001173343.1
Coordinates 749158..749331 (-) Length 58 a.a.

Antitoxin (Protein)


Gene name ghoS Uniprot ID L4JK92
Locus tag O6R07_RS03800 Protein ID WP_000398619.1
Coordinates 749359..749655 (-) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
O6R07_RS03785 (745828) 745828..747285 + 1458 WP_000856829.1 dipeptide/tripeptide permease DtpC -
O6R07_RS03790 (747522) 747522..749039 + 1518 WP_001295074.1 lysine--tRNA ligase -
O6R07_RS03795 (749158) 749158..749331 - 174 WP_001173343.1 type V toxin-antitoxin system toxin GhoT Toxin
O6R07_RS03800 (749359) 749359..749655 - 297 WP_000398619.1 type V toxin-antitoxin system endoribonuclease antitoxin GhoS Antitoxin
O6R07_RS03805 (749882) 749882..750154 - 273 WP_000405651.1 GNAT family N-acetyltransferase -
O6R07_RS03810 (750166) 750166..750396 - 231 WP_000371704.1 4Fe-4S mono-cluster protein YjdI -
O6R07_RS03815 (750577) 750577..752208 + 1632 WP_001216477.1 sensor histidine kinase -
O6R07_RS03820 (752205) 752205..752924 + 720 WP_000611288.1 two-component system response regulator DcuR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin GhoT/OrtT

(4-57)

Antitoxin

Endoribonuclease antitoxin GhoS

(5-94)


Sequences

Toxin        


Download         Length: 58 a.a.        Molecular weight: 6555.06 Da        Isoelectric Point: 10.2288

>T266947 WP_001173343.1 NZ_CP114893:c749331-749158 [Escherichia coli]
MALFSKILIFYVIGVNISFVIIWFISHEKTHIRLLSAFLVGITWPMSLPVALLFSLF

Download         Length: 174 bp

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11467.97 Da        Isoelectric Point: 4.1705

>AT266947 WP_000398619.1 NZ_CP114893:c749655-749359 [Escherichia coli]
MEGKNKFNTYVVSFDYPSSYSSVFLRLRSLMYDMNFSSIVADEYGIPRQLNENSFAITTSLAASEIEDLIRLKCLDLPDI
DFDLNIMTVDDYFRQFYK

Download         Length: 297 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9QI41

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBH6

References