Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 653197..653792 Replicon chromosome
Accession NZ_CP114893
Organism Escherichia coli strain CM13

Toxin (Protein)


Gene name chpB Uniprot ID U9XNP6
Locus tag O6R07_RS03300 Protein ID WP_000239577.1
Coordinates 653197..653547 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID U9Y2K1
Locus tag O6R07_RS03305 Protein ID WP_001223208.1
Coordinates 653541..653792 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
O6R07_RS03280 (649534) 649534..649665 - 132 Protein_641 ABC transporter permease -
O6R07_RS03285 (649679) 649679..651181 - 1503 WP_000205805.1 sugar ABC transporter ATP-binding protein -
O6R07_RS03290 (651321) 651321..652277 - 957 WP_000265913.1 galactofuranose ABC transporter substrate-binding protein YtfQ -
O6R07_RS03295 (652587) 652587..653117 + 531 WP_000055075.1 inorganic diphosphatase -
O6R07_RS03300 (653197) 653197..653547 - 351 WP_000239577.1 endoribonuclease toxin ChpB Toxin
O6R07_RS03305 (653541) 653541..653792 - 252 WP_001223208.1 type II toxin-antitoxin system antitoxin ChpS Antitoxin
O6R07_RS03310 (654004) 654004..654345 - 342 WP_001219160.1 gamma-glutamylcyclotransferase -
O6R07_RS03315 (654348) 654348..658127 - 3780 WP_000060911.1 autotransporter assembly complex protein TamB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-114)

Antitoxin

SpoVT-AbrB domain

(6-49)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12492.40 Da        Isoelectric Point: 5.5572

>T266946 WP_000239577.1 NZ_CP114893:c653547-653197 [Escherichia coli]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVRMMDLHARLAKRIGLAADEVVEEALLRLQAVVE

Download         Length: 351 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9271.58 Da        Isoelectric Point: 4.4201

>AT266946 WP_001223208.1 NZ_CP114893:c653792-653541 [Escherichia coli]
MRITIKRWGNSAGMVIPNIVMKELNLQPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNAAELSEQDVWGKSTPAGD
EIW

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U9XNP6

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LQ26

References