Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yjhX-yjhQ/YjhX-GNAT
Location 566740..567554 Replicon chromosome
Accession NZ_CP114893
Organism Escherichia coli strain CM13

Toxin (Protein)


Gene name yjhX Uniprot ID S1PA82
Locus tag O6R07_RS02860 Protein ID WP_001054376.1
Coordinates 566740..566997 (+) Length 86 a.a.

Antitoxin (Protein)


Gene name yjhQ Uniprot ID U9Z4B8
Locus tag O6R07_RS02865 Protein ID WP_001309181.1
Coordinates 567009..567554 (+) Length 182 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
O6R07_RS02835 (562028) 562028..563134 + 1107 WP_001309184.1 N-acetylneuraminate epimerase -
O6R07_RS02840 (563199) 563199..564179 + 981 WP_000991438.1 9-O-acetyl-N-acetylneuraminic acid deacetylase -
O6R07_RS02845 (564289) 564289..564494 + 206 Protein_555 HNH endonuclease -
O6R07_RS02850 (564762) 564762..566002 - 1241 Protein_556 helicase YjhR -
O6R07_RS02855 (566118) 566118..566249 + 132 WP_001309182.1 hypothetical protein -
O6R07_RS02860 (566740) 566740..566997 + 258 WP_001054376.1 YjhX family toxin Toxin
O6R07_RS02865 (567009) 567009..567554 + 546 WP_001309181.1 N-acetyltransferase Antitoxin
O6R07_RS02870 (567610) 567610..568356 + 747 WP_000354251.1 class I SAM-dependent methyltransferase -
O6R07_RS02875 (568525) 568525..568743 + 219 Protein_561 hypothetical protein -
O6R07_RS02880 (568781) 568781..568897 + 117 Protein_562 VOC family protein -
O6R07_RS02885 (569142) 569142..570263 + 1122 WP_000010829.1 M42 family metallopeptidase -
O6R07_RS02890 (570260) 570260..570538 + 279 WP_000722973.1 PTS sugar transporter subunit IIB SgcB -
O6R07_RS02895 (570550) 570550..571863 + 1314 WP_000460843.1 PTS sugar transporter subunit IIC SgcC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 551937..575778 23841


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Putative toxin of bacterial toxin-antitoxin pair

(1-85)

Antitoxin

GNAT domain

(18-121)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9734.29 Da        Isoelectric Point: 11.0090

>T266945 WP_001054376.1 NZ_CP114893:566740-566997 [Escherichia coli]
MNLSRQEQHTLHVLAKGRRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTELNKVRA
QLDNR

Download         Length: 258 bp

Antitoxin


Download         Length: 182 a.a.        Molecular weight: 19956.90 Da        Isoelectric Point: 6.3277

>AT266945 WP_001309181.1 NZ_CP114893:567009-567554 [Escherichia coli]
MTVHHFTFHITDKSDASDIREVETRAFGFSKEADLVASLLEDESARPALSLLARYEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQSLTA
QPMTLTGHIRCADPDETGALT

Download         Length: 546 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1PA82

Antitoxin

Source ID Structure
AlphaFold DB U9Z4B8

References