266941

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 93885..94503 Replicon chromosome
Accession NZ_CP114893
Organism Escherichia coli strain CM13

Toxin (Protein)


Gene name Hha Uniprot ID -
Locus tag O6R07_RS00475 Protein ID WP_001290581.1
Coordinates 94285..94503 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag O6R07_RS00470 Protein ID WP_000344800.1
Coordinates 93885..94259 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
O6R07_RS00460 (88974) 88974..90167 + 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
O6R07_RS00465 (90190) 90190..93339 + 3150 WP_001132469.1 efflux RND transporter permease AcrB -
O6R07_RS00470 (93885) 93885..94259 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
O6R07_RS00475 (94285) 94285..94503 + 219 WP_001290581.1 HHA domain-containing protein Toxin
O6R07_RS00480 (94675) 94675..95226 + 552 WP_000102564.1 maltose O-acetyltransferase -
O6R07_RS00485 (95342) 95342..95812 + 471 WP_000136192.1 YlaC family protein -
O6R07_RS00490 (95976) 95976..97526 + 1551 WP_001310610.1 cyclic-guanylate-specific phosphodiesterase PdeB -
O6R07_RS00495 (97568) 97568..97921 - 354 WP_000878140.1 DUF1428 domain-containing protein -
O6R07_RS00505 (98300) 98300..98611 + 312 WP_000409911.1 MGMT family protein -
O6R07_RS00510 (98642) 98642..99214 - 573 WP_000779842.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8678.06 Da        Isoelectric Point: 8.9008

>T266941 WP_001290581.1 NZ_CP114893:94285-94503 [Escherichia coli]
MSEKFLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT266941 WP_000344800.1 NZ_CP114893:93885-94259 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References