Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 2266529..2267183 Replicon chromosome
Accession NZ_CP114892
Organism Escherichia coli strain CM5

Toxin (Protein)


Gene name cptA Uniprot ID S1EEB2
Locus tag O6Q95_RS11135 Protein ID WP_000244777.1
Coordinates 2266529..2266936 (-) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag O6Q95_RS11140 Protein ID WP_000354046.1
Coordinates 2266917..2267183 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
O6Q95_RS11115 (2262486) 2262486..2264219 - 1734 WP_000813200.1 single-stranded-DNA-specific exonuclease RecJ -
O6Q95_RS11120 (2264225) 2264225..2264935 - 711 WP_000715214.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
O6Q95_RS11125 (2264960) 2264960..2265856 - 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
O6Q95_RS11130 (2265968) 2265968..2266489 + 522 WP_001055874.1 flavodoxin FldB -
O6Q95_RS11135 (2266529) 2266529..2266936 - 408 WP_000244777.1 protein YgfX Toxin
O6Q95_RS11140 (2266917) 2266917..2267183 - 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
O6Q95_RS11145 (2267426) 2267426..2268406 + 981 WP_000886062.1 tRNA-modifying protein YgfZ -
O6Q95_RS11150 (2268602) 2268602..2269261 - 660 WP_000250274.1 hemolysin III family protein -
O6Q95_RS11155 (2269425) 2269425..2269736 - 312 WP_001182957.1 N(4)-acetylcytidine aminohydrolase -
O6Q95_RS11160 (2269781) 2269781..2271214 + 1434 WP_001336277.1 6-phospho-beta-glucosidase BglA -
O6Q95_RS11165 (2271271) 2271271..2272014 - 744 WP_000951964.1 SDR family oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16031.96 Da        Isoelectric Point: 11.5202

>T266930 WP_000244777.1 NZ_CP114892:c2266936-2266529 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDGGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT266930 WP_000354046.1 NZ_CP114892:c2267183-2266917 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9LFV7

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References