Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yfjZ-ypjF/CbtA-CbeA
Location 1996006..1996673 Replicon chromosome
Accession NZ_CP114892
Organism Escherichia coli strain CM5

Toxin (Protein)


Gene name ypjF Uniprot ID Q46953
Locus tag O6Q95_RS09865 Protein ID WP_001094400.1
Coordinates 1996344..1996673 (+) Length 110 a.a.

Antitoxin (Protein)


Gene name yfjZ Uniprot ID P52141
Locus tag O6Q95_RS09860 Protein ID WP_000072690.1
Coordinates 1996006..1996323 (+) Length 106 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
O6Q95_RS09830 (1991058) 1991058..1992067 - 1010 Protein_1928 arsenic transporter -
O6Q95_RS09835 (1992209) 1992209..1993912 + 1704 WP_000896263.1 protein YfjW -
O6Q95_RS09840 (1994523) 1994523..1994707 + 185 Protein_1930 DUF905 family protein -
O6Q95_RS09845 (1994810) 1994810..1995268 + 459 WP_000211841.1 antirestriction protein -
O6Q95_RS09850 (1995277) 1995277..1995759 + 483 WP_001407480.1 RadC family protein -
O6Q95_RS09855 (1995768) 1995768..1995968 + 201 WP_001395452.1 DUF987 domain-containing protein -
O6Q95_RS09860 (1996006) 1996006..1996323 + 318 WP_000072690.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
O6Q95_RS09865 (1996344) 1996344..1996673 + 330 WP_001094400.1 type IV toxin-antitoxin system toxin YpjF Toxin
O6Q95_RS09870 (1997037) 1997037..2001617 - 4581 WP_010723187.1 adhesin-like autotransporter YpjA/EhaD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-108)

Antitoxin

Antitoxin CbeA

(5-104)


Sequences

Toxin        


Download         Length: 110 a.a.        Molecular weight: 12308.21 Da        Isoelectric Point: 7.2761

>T266928 WP_001094400.1 NZ_CP114892:1996344-1996673 [Escherichia coli]
MNTLPATISQAAKPCLSPVAVWQMLLTRLLEQHYGLTLNDTPFSDETVIKEHIDAGITLADAVNFLVEKYELVRIDHRGF
SWQQQSPYISVVDILRARRSTGLLKTNVK

Download         Length: 330 bp

Antitoxin


Download         Length: 106 a.a.        Molecular weight: 11737.27 Da        Isoelectric Point: 6.4630

>AT266928 WP_000072690.1 NZ_CP114892:1996006-1996323 [Escherichia coli]
MSNTTWGLQRDITPRLGARLVQEGNQLHYLADRASITGKFSDAECPKLDVVFPHFISQIESMLTTGELNPRHAQCVTLYH
NGFTCEADTLGSCGYVYIAVYPTQR

Download         Length: 318 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A373F4I3

Antitoxin

Source ID Structure
PDB 2EA9
PDB 2JN7
AlphaFold DB P52141

References