Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 728266..728904 Replicon chromosome
Accession NZ_CP114892
Organism Escherichia coli strain CM5

Toxin (Protein)


Gene name hicA Uniprot ID S1F9G9
Locus tag O6Q95_RS03635 Protein ID WP_000813794.1
Coordinates 728266..728442 (+) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag O6Q95_RS03640 Protein ID WP_001270286.1
Coordinates 728488..728904 (+) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
O6Q95_RS03615 (723885) 723885..725060 - 1176 WP_001236265.1 BenE family transporter YdcO -
O6Q95_RS03620 (725152) 725152..725688 + 537 WP_000429155.1 DNA-binding transcriptional regulator SutR -
O6Q95_RS03625 (725761) 725761..727722 + 1962 WP_001303492.1 23S rRNA 5-hydroxycytidine C2501 synthase -
O6Q95_RS03630 (727814) 727814..728044 - 231 WP_000494244.1 YncJ family protein -
O6Q95_RS03635 (728266) 728266..728442 + 177 WP_000813794.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
O6Q95_RS03640 (728488) 728488..728904 + 417 WP_001270286.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
O6Q95_RS03645 (728983) 728983..730389 + 1407 WP_000760626.1 PLP-dependent aminotransferase family protein -
O6Q95_RS03650 (730634) 730634..731779 + 1146 WP_000047424.1 ABC transporter substrate-binding protein -
O6Q95_RS03655 (731797) 731797..732810 + 1014 WP_000220396.1 ABC transporter ATP-binding protein -
O6Q95_RS03660 (732811) 732811..733752 + 942 WP_001251304.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

Cro/C1-type helix-turn-helix domain

(91-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6749.83 Da        Isoelectric Point: 11.2298

>T266918 WP_000813794.1 NZ_CP114892:728266-728442 [Escherichia coli]
VKQSEFRRWLESQGVDVANGSNHLKLRFHGRRSVMPRHPCDEIKEPLRKAILKQLGLS

Download         Length: 177 bp

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15246.63 Da        Isoelectric Point: 4.7386

>AT266918 WP_001270286.1 NZ_CP114892:728488-728904 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6HPB

Antitoxin

Source ID Structure

References