Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type V Classification (family/domain) ghoTS/ghoT-GhoS
Location 3582774..3583271 Replicon chromosome
Accession NZ_CP114891
Organism Escherichia coli strain CM2

Toxin (Protein)


Gene name ghoT Uniprot ID L4JJG6
Locus tag O6Q44_RS17740 Protein ID WP_001173343.1
Coordinates 3582774..3582947 (-) Length 58 a.a.

Antitoxin (Protein)


Gene name ghoS Uniprot ID L4JK92
Locus tag O6Q44_RS17745 Protein ID WP_000398619.1
Coordinates 3582975..3583271 (-) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
O6Q44_RS17730 (3579444) 3579444..3580901 + 1458 WP_000856829.1 dipeptide/tripeptide permease DtpC -
O6Q44_RS17735 (3581138) 3581138..3582655 + 1518 WP_001295074.1 lysine--tRNA ligase -
O6Q44_RS17740 (3582774) 3582774..3582947 - 174 WP_001173343.1 type V toxin-antitoxin system toxin GhoT Toxin
O6Q44_RS17745 (3582975) 3582975..3583271 - 297 WP_000398619.1 type V toxin-antitoxin system endoribonuclease antitoxin GhoS Antitoxin
O6Q44_RS17750 (3583498) 3583498..3583770 - 273 WP_000405651.1 GNAT family N-acetyltransferase -
O6Q44_RS17755 (3583782) 3583782..3584012 - 231 WP_000371704.1 4Fe-4S mono-cluster protein YjdI -
O6Q44_RS17760 (3584193) 3584193..3585824 + 1632 WP_001216477.1 sensor histidine kinase -
O6Q44_RS17765 (3585821) 3585821..3586540 + 720 WP_000611288.1 two-component system response regulator DcuR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin GhoT/OrtT

(4-57)

Antitoxin

Endoribonuclease antitoxin GhoS

(5-94)


Sequences

Toxin        


Download         Length: 58 a.a.        Molecular weight: 6555.06 Da        Isoelectric Point: 10.2288

>T266914 WP_001173343.1 NZ_CP114891:c3582947-3582774 [Escherichia coli]
MALFSKILIFYVIGVNISFVIIWFISHEKTHIRLLSAFLVGITWPMSLPVALLFSLF

Download         Length: 174 bp

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11467.97 Da        Isoelectric Point: 4.1705

>AT266914 WP_000398619.1 NZ_CP114891:c3583271-3582975 [Escherichia coli]
MEGKNKFNTYVVSFDYPSSYSSVFLRLRSLMYDMNFSSIVADEYGIPRQLNENSFAITTSLAASEIEDLIRLKCLDLPDI
DFDLNIMTVDDYFRQFYK

Download         Length: 297 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9QI41

Antitoxin

Source ID Structure
PDB 2LLZ
AlphaFold DB A0A7U9QBH6

References