Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 3486813..3487408 Replicon chromosome
Accession NZ_CP114891
Organism Escherichia coli strain CM2

Toxin (Protein)


Gene name chpB Uniprot ID U9XNP6
Locus tag O6Q44_RS17245 Protein ID WP_000239577.1
Coordinates 3486813..3487163 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID U9Y2K1
Locus tag O6Q44_RS17250 Protein ID WP_001223208.1
Coordinates 3487157..3487408 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
O6Q44_RS17225 (3483150) 3483150..3483281 - 132 Protein_3362 ABC transporter permease -
O6Q44_RS17230 (3483295) 3483295..3484797 - 1503 WP_000205805.1 sugar ABC transporter ATP-binding protein -
O6Q44_RS17235 (3484937) 3484937..3485893 - 957 WP_000265913.1 galactofuranose ABC transporter substrate-binding protein YtfQ -
O6Q44_RS17240 (3486203) 3486203..3486733 + 531 WP_000055075.1 inorganic diphosphatase -
O6Q44_RS17245 (3486813) 3486813..3487163 - 351 WP_000239577.1 endoribonuclease toxin ChpB Toxin
O6Q44_RS17250 (3487157) 3487157..3487408 - 252 WP_001223208.1 type II toxin-antitoxin system antitoxin ChpS Antitoxin
O6Q44_RS17255 (3487620) 3487620..3487961 - 342 WP_001219160.1 gamma-glutamylcyclotransferase -
O6Q44_RS17260 (3487964) 3487964..3491743 - 3780 WP_000060911.1 autotransporter assembly complex protein TamB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-114)

Antitoxin

SpoVT-AbrB domain

(6-49)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12492.40 Da        Isoelectric Point: 5.5572

>T266913 WP_000239577.1 NZ_CP114891:c3487163-3486813 [Escherichia coli]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVRMMDLHARLAKRIGLAADEVVEEALLRLQAVVE

Download         Length: 351 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9271.58 Da        Isoelectric Point: 4.4201

>AT266913 WP_001223208.1 NZ_CP114891:c3487408-3487157 [Escherichia coli]
MRITIKRWGNSAGMVIPNIVMKELNLQPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNAAELSEQDVWGKSTPAGD
EIW

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U9XNP6

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LQ26

References