266912

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yjhX-yjhQ/YjhX-GNAT
Location 3400355..3401169 Replicon chromosome
Accession NZ_CP114891
Organism Escherichia coli strain CM2

Toxin (Protein)


Gene name yjhX Uniprot ID S1PA82
Locus tag O6Q44_RS16805 Protein ID WP_001054376.1
Coordinates 3400355..3400612 (+) Length 86 a.a.

Antitoxin (Protein)


Gene name yjhQ Uniprot ID U9Z4B8
Locus tag O6Q44_RS16810 Protein ID WP_001309181.1
Coordinates 3400624..3401169 (+) Length 182 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
O6Q44_RS16780 (3395643) 3395643..3396749 + 1107 WP_001309184.1 N-acetylneuraminate epimerase -
O6Q44_RS16785 (3396814) 3396814..3397794 + 981 WP_000991438.1 9-O-acetyl-N-acetylneuraminic acid deacetylase -
O6Q44_RS16790 (3397904) 3397904..3398109 + 206 Protein_3276 HNH endonuclease -
O6Q44_RS16795 (3398377) 3398377..3399617 - 1241 Protein_3277 helicase YjhR -
O6Q44_RS16800 (3399733) 3399733..3399864 + 132 WP_001309182.1 hypothetical protein -
O6Q44_RS16805 (3400355) 3400355..3400612 + 258 WP_001054376.1 YjhX family toxin Toxin
O6Q44_RS16810 (3400624) 3400624..3401169 + 546 WP_001309181.1 N-acetyltransferase Antitoxin
O6Q44_RS16815 (3401225) 3401225..3401971 + 747 WP_000354251.1 class I SAM-dependent methyltransferase -
O6Q44_RS16820 (3402140) 3402140..3402358 + 219 Protein_3282 hypothetical protein -
O6Q44_RS16825 (3402396) 3402396..3402512 + 117 Protein_3283 VOC family protein -
O6Q44_RS16830 (3402757) 3402757..3403878 + 1122 WP_000010829.1 M42 family metallopeptidase -
O6Q44_RS16835 (3403875) 3403875..3404153 + 279 WP_000722973.1 PTS sugar transporter subunit IIB SgcB -
O6Q44_RS16840 (3404165) 3404165..3405478 + 1314 WP_000460843.1 PTS sugar transporter subunit IIC SgcC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 3385552..3409393 23841


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Putative toxin of bacterial toxin-antitoxin pair

(1-85)

Antitoxin

GNAT domain

(18-121)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9734.29 Da        Isoelectric Point: 11.0090

>T266912 WP_001054376.1 NZ_CP114891:3400355-3400612 [Escherichia coli]
MNLSRQEQHTLHVLAKGRRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTELNKVRA
QLDNR

Download         Length: 258 bp

Antitoxin


Download         Length: 182 a.a.        Molecular weight: 19956.90 Da        Isoelectric Point: 6.3277

>AT266912 WP_001309181.1 NZ_CP114891:3400624-3401169 [Escherichia coli]
MTVHHFTFHITDKSDASDIREVETRAFGFSKEADLVASLLEDESARPALSLLARYEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQSLTA
QPMTLTGHIRCADPDETGALT

Download         Length: 546 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1PA82

Antitoxin

Source ID Structure
AlphaFold DB U9Z4B8

References