Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 2927500..2928118 Replicon chromosome
Accession NZ_CP114891
Organism Escherichia coli strain CM2

Toxin (Protein)


Gene name Hha Uniprot ID -
Locus tag O6Q44_RS14415 Protein ID WP_001290581.1
Coordinates 2927900..2928118 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag O6Q44_RS14410 Protein ID WP_000344800.1
Coordinates 2927500..2927874 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
O6Q44_RS14400 (2922589) 2922589..2923782 + 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
O6Q44_RS14405 (2923805) 2923805..2926954 + 3150 WP_001132469.1 efflux RND transporter permease AcrB -
O6Q44_RS14410 (2927500) 2927500..2927874 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
O6Q44_RS14415 (2927900) 2927900..2928118 + 219 WP_001290581.1 HHA domain-containing protein Toxin
O6Q44_RS14420 (2928290) 2928290..2928841 + 552 WP_000102564.1 maltose O-acetyltransferase -
O6Q44_RS14425 (2928957) 2928957..2929427 + 471 WP_000136192.1 YlaC family protein -
O6Q44_RS14430 (2929591) 2929591..2931141 + 1551 WP_001310610.1 cyclic-guanylate-specific phosphodiesterase PdeB -
O6Q44_RS14435 (2931183) 2931183..2931536 - 354 WP_000878140.1 DUF1428 domain-containing protein -
O6Q44_RS14445 (2931915) 2931915..2932226 + 312 WP_000409911.1 MGMT family protein -
O6Q44_RS14450 (2932257) 2932257..2932829 - 573 WP_000779842.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8678.06 Da        Isoelectric Point: 8.9008

>T266908 WP_001290581.1 NZ_CP114891:2927900-2928118 [Escherichia coli]
MSEKFLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT266908 WP_000344800.1 NZ_CP114891:2927500-2927874 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References