Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 1857084..1857722 Replicon chromosome
Accession NZ_CP114891
Organism Escherichia coli strain CM2

Toxin (Protein)


Gene name hicA Uniprot ID S1F9G9
Locus tag O6Q44_RS09105 Protein ID WP_000813794.1
Coordinates 1857546..1857722 (-) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag O6Q44_RS09100 Protein ID WP_001270286.1
Coordinates 1857084..1857500 (-) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
O6Q44_RS09080 (1852236) 1852236..1853177 - 942 WP_001251304.1 ABC transporter permease -
O6Q44_RS09085 (1853178) 1853178..1854191 - 1014 WP_000220396.1 ABC transporter ATP-binding protein -
O6Q44_RS09090 (1854209) 1854209..1855354 - 1146 WP_000047424.1 ABC transporter substrate-binding protein -
O6Q44_RS09095 (1855599) 1855599..1857005 - 1407 WP_000760626.1 PLP-dependent aminotransferase family protein -
O6Q44_RS09100 (1857084) 1857084..1857500 - 417 WP_001270286.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
O6Q44_RS09105 (1857546) 1857546..1857722 - 177 WP_000813794.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
O6Q44_RS09110 (1857944) 1857944..1858174 + 231 WP_000494244.1 YncJ family protein -
O6Q44_RS09115 (1858266) 1858266..1860227 - 1962 WP_001303492.1 23S rRNA 5-hydroxycytidine C2501 synthase -
O6Q44_RS09120 (1860300) 1860300..1860836 - 537 WP_000429155.1 DNA-binding transcriptional regulator SutR -
O6Q44_RS09125 (1860928) 1860928..1862103 + 1176 WP_001236265.1 BenE family transporter YdcO -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

Cro/C1-type helix-turn-helix domain

(91-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6749.83 Da        Isoelectric Point: 11.2298

>T266907 WP_000813794.1 NZ_CP114891:c1857722-1857546 [Escherichia coli]
VKQSEFRRWLESQGVDVANGSNHLKLRFHGRRSVMPRHPCDEIKEPLRKAILKQLGLS

Download         Length: 177 bp

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15246.63 Da        Isoelectric Point: 4.7386

>AT266907 WP_001270286.1 NZ_CP114891:c1857500-1857084 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6HPB

Antitoxin

Source ID Structure

References