266897

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yfjZ-ypjF/CbtA-CbeA
Location 589319..589986 Replicon chromosome
Accession NZ_CP114891
Organism Escherichia coli strain CM2

Toxin (Protein)


Gene name ypjF Uniprot ID Q46953
Locus tag O6Q44_RS02880 Protein ID WP_001094400.1
Coordinates 589319..589648 (-) Length 110 a.a.

Antitoxin (Protein)


Gene name yfjZ Uniprot ID P52141
Locus tag O6Q44_RS02885 Protein ID WP_000072690.1
Coordinates 589669..589986 (-) Length 106 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
O6Q44_RS02875 (584375) 584375..588955 + 4581 WP_010723187.1 adhesin-like autotransporter YpjA/EhaD -
O6Q44_RS02880 (589319) 589319..589648 - 330 WP_001094400.1 type IV toxin-antitoxin system toxin YpjF Toxin
O6Q44_RS02885 (589669) 589669..589986 - 318 WP_000072690.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
O6Q44_RS02890 (590024) 590024..590224 - 201 WP_001395452.1 DUF987 domain-containing protein -
O6Q44_RS02895 (590233) 590233..590715 - 483 WP_001407480.1 RadC family protein -
O6Q44_RS02900 (590724) 590724..591182 - 459 WP_000211841.1 antirestriction protein -
O6Q44_RS02905 (591285) 591285..591469 - 185 Protein_564 DUF905 family protein -
O6Q44_RS02910 (592080) 592080..593783 - 1704 WP_000896263.1 protein YfjW -
O6Q44_RS02915 (593925) 593925..594934 + 1010 Protein_566 arsenic transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-108)

Antitoxin

Antitoxin CbeA

(5-104)


Sequences

Toxin        


Download         Length: 110 a.a.        Molecular weight: 12308.21 Da        Isoelectric Point: 7.2761

>T266897 WP_001094400.1 NZ_CP114891:c589648-589319 [Escherichia coli]
MNTLPATISQAAKPCLSPVAVWQMLLTRLLEQHYGLTLNDTPFSDETVIKEHIDAGITLADAVNFLVEKYELVRIDHRGF
SWQQQSPYISVVDILRARRSTGLLKTNVK

Download         Length: 330 bp

Antitoxin


Download         Length: 106 a.a.        Molecular weight: 11737.27 Da        Isoelectric Point: 6.4630

>AT266897 WP_000072690.1 NZ_CP114891:c589986-589669 [Escherichia coli]
MSNTTWGLQRDITPRLGARLVQEGNQLHYLADRASITGKFSDAECPKLDVVFPHFISQIESMLTTGELNPRHAQCVTLYH
NGFTCEADTLGSCGYVYIAVYPTQR

Download         Length: 318 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A373F4I3

Antitoxin

Source ID Structure
AlphaFold DB P52141

References