Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumA-relB/upstrm_HI1419-dnstrm_HI1420
Location 5989018..5989684 Replicon chromosome
Accession NZ_CP114886
Organism Endozoicomonas sp. GU-1 strain Ap1-3

Toxin (Protein)


Gene name PumA Uniprot ID -
Locus tag O2T12_RS25055 Protein ID WP_269671943.1
Coordinates 5989018..5989395 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag O2T12_RS25060 Protein ID WP_269671944.1
Coordinates 5989397..5989684 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
O2T12_RS25030 (O2T12_25030) 5985661..5986830 + 1170 WP_269675990.1 nucleotide sugar dehydrogenase -
O2T12_RS25035 (O2T12_25035) 5987091..5987519 + 429 WP_269671939.1 nucleotidyltransferase substrate binding protein -
O2T12_RS25040 (O2T12_25040) 5987519..5987848 + 330 WP_269671940.1 nucleotidyltransferase domain-containing protein -
O2T12_RS25045 (O2T12_25045) 5988169..5988459 + 291 WP_269671941.1 nucleotidyltransferase family protein -
O2T12_RS25050 (O2T12_25050) 5988456..5988821 + 366 WP_269671942.1 DUF86 domain-containing protein -
O2T12_RS25055 (O2T12_25055) 5989018..5989395 + 378 WP_269671943.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
O2T12_RS25060 (O2T12_25060) 5989397..5989684 + 288 WP_269671944.1 putative addiction module antidote protein Antitoxin
O2T12_RS25065 (O2T12_25065) 5989846..5990145 + 300 WP_269671945.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein -
O2T12_RS25070 (O2T12_25070) 5990181..5990633 + 453 WP_269671946.1 winged helix-turn-helix domain-containing protein -
O2T12_RS25075 (O2T12_25075) 5990660..5991220 + 561 WP_269675991.1 IS630 family transposase -
O2T12_RS25080 (O2T12_25080) 5991239..5991364 + 126 WP_269671947.1 hypothetical protein -
O2T12_RS25085 (O2T12_25085) 5991358..5991654 + 297 WP_269675992.1 hypothetical protein -
O2T12_RS25090 (O2T12_25090) 5991756..5993012 + 1257 WP_269671948.1 hypothetical protein -
O2T12_RS25095 (O2T12_25095) 5993018..5993932 + 915 WP_269676662.1 glycosyltransferase family 2 protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(29-124)

Antitoxin

Uncharacterized protein HI1420

(5-92)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14379.75 Da        Isoelectric Point: 9.8022

>T266890 WP_269671943.1 NZ_CP114886:5989018-5989395 [Endozoicomonas sp. GU-1]
MKDLTPGFFPFFVCELEYVSKWIHNSLMYLLKTTDHFEKWLHKLKDKQGKARILASLKLLEQGHIGDWKSVGGKVSELRV
HYGAGYRIYFARQEDVIIVLLNGGDKASQSRDIEKAKAILKNLEA

Download         Length: 378 bp

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10227.72 Da        Isoelectric Point: 5.8062

>AT266890 WP_269671944.1 NZ_CP114886:5989397-5989684 [Endozoicomonas sp. GU-1]
MSRKLKTFDASEYLDDSETIAEYLNAVIETGDQALLLSAIGDIAKATGMQKIANDSGLGRESLYKALAPGAKPRFDTVFK
ILQALGVSLKISPQH

Download         Length: 288 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References