Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Xre-MNT/HTH_26(antitoxin)
Location 1397358..1398466 Replicon chromosome
Accession NZ_CP114883
Organism Streptococcus alactolyticus strain LGM

Toxin (Protein)


Gene name MNTss Uniprot ID R3JIN1
Locus tag O6R09_RS07160 Protein ID WP_000233000.1
Coordinates 1397358..1398227 (-) Length 290 a.a.

Antitoxin (Protein)


Gene name Xress Uniprot ID -
Locus tag O6R09_RS07165 Protein ID WP_000205227.1
Coordinates 1398242..1398466 (-) Length 75 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
O6R09_RS07130 (O6R09_07130) 1392826..1393833 - 1008 WP_269725562.1 AraC family transcriptional regulator -
O6R09_RS07135 (O6R09_07135) 1393870..1394076 - 207 Protein_1344 AraC family transcriptional regulator -
O6R09_RS07140 (O6R09_07140) 1394256..1395044 - 789 WP_055275145.1 aminoglycoside nucleotidyltransferase ANT(9) -
O6R09_RS07145 (O6R09_07145) 1395176..1395703 - 528 WP_002294507.1 phosphoribosyltransferase family protein -
O6R09_RS07150 (O6R09_07150) 1395747..1396610 - 864 WP_002294505.1 aminoglycoside nucleotidyltransferase ANT(6)-Ia -
O6R09_RS07155 (O6R09_07155) 1396643..1397377 - 735 WP_000662263.1 class I SAM-dependent methyltransferase -
O6R09_RS07160 (O6R09_07160) 1397358..1398227 - 870 WP_000233000.1 nucleotidyltransferase domain-containing protein Toxin
O6R09_RS07165 (O6R09_07165) 1398242..1398466 - 225 WP_000205227.1 helix-turn-helix transcriptional regulator Antitoxin
O6R09_RS07170 (O6R09_07170) 1398609..1398695 - 87 Protein_1351 site-specific recombinase -
O6R09_RS07175 (O6R09_07175) 1398904..1400186 + 1283 Protein_1352 ISL3 family transposase -
O6R09_RS07180 (O6R09_07180) 1400495..1401298 - 804 WP_002294514.1 lincosamide nucleotidyltransferase Lnu(B) -
O6R09_RS07185 (O6R09_07185) 1401352..1402836 - 1485 WP_002294513.1 ABC-F type ribosomal protection protein Lsa(E) -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Polymerase, nucleotidyl transferase domain

(12-111)

Antitoxin

Cro/C1-type helix-turn-helix domain

(4-57)


Sequences

Toxin        


Download         Length: 290 a.a.        Molecular weight: 32926.57 Da        Isoelectric Point: 4.8781

>T266877 WP_000233000.1 NZ_CP114883:c1398227-1397358 [Streptococcus alactolyticus]
MVGNVIQIVTEKLSSLPFIEGIVLGGSRARGTHTENSDIDIGIYYNSDSFDLTAINQIATELDDKNRNNLVVPPGAWGDW
INGGGWLFINGYHVDLILRDIKRVEQIIKDTEQGIVTANYQTGHPHGYISAMYRGELAISKILYAKNESLCELKKQAEIY
PTALKKSLMNFFIFEAEFSLMFVKANAGVEDKYYIAGHVFRIISCLNQVLFACNNAYCINEKKAIKLLETFEYKPEKYAE
RVNHIFEVLGLSLFECYDMTEKLYKEVNEIVSEINNFLNEESSDERKQI

Download         Length: 870 bp

Antitoxin


Download         Length: 75 a.a.        Molecular weight: 8365.68 Da        Isoelectric Point: 4.5510

>AT266877 WP_000205227.1 NZ_CP114883:c1398466-1398242 [Streptococcus alactolyticus]
MTTAEMIKELCEQMNISVSELARRIGQTPQNFNKKLQRETVTLDELKAIADVLGVKFVQAFILPDGEEIKISNE

Download         Length: 225 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB R3JIN1

Antitoxin

Source ID Structure

References