Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemIK/PRK09907-MazE
Location 31601..32202 Replicon plasmid pLL441-1
Accession NZ_CP114875
Organism Lactiplantibacillus plantarum strain LL441

Toxin (Protein)


Gene name pemK Uniprot ID Q684P1
Locus tag O4Z47_RS14515 Protein ID WP_001748110.1
Coordinates 31858..32202 (+) Length 115 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID Q684P2
Locus tag O4Z47_RS14510 Protein ID WP_003643337.1
Coordinates 31601..31864 (+) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
O4Z47_RS14475 (O4Z47_14475) 26824..27066 + 243 WP_062688575.1 hypothetical protein -
O4Z47_RS14480 (O4Z47_14480) 27972..29075 + 1104 WP_070085094.1 replication initiator protein A -
O4Z47_RS14485 (O4Z47_14485) 29220..29444 + 225 WP_070085095.1 hypothetical protein -
O4Z47_RS14490 (O4Z47_14490) 29643..30119 + 477 WP_070085096.1 GNAT family N-acetyltransferase -
O4Z47_RS14495 (O4Z47_14495) 30153..30431 - 279 WP_070085097.1 hypothetical protein -
O4Z47_RS14500 (O4Z47_14500) 30448..30660 - 213 WP_070085098.1 hypothetical protein -
O4Z47_RS14505 (O4Z47_14505) 30928..31515 - 588 WP_003646144.1 site-specific integrase -
O4Z47_RS14510 (O4Z47_14510) 31601..31864 + 264 WP_003643337.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
O4Z47_RS14515 (O4Z47_14515) 31858..32202 + 345 WP_001748110.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
O4Z47_RS14520 (O4Z47_14520) 32323..32535 - 213 WP_015063544.1 DUF3923 family protein -
O4Z47_RS14525 (O4Z47_14525) 32774..33250 + 477 WP_070084968.1 DUF536 domain-containing protein -
O4Z47_RS14530 (O4Z47_14530) 33955..34332 + 378 WP_003646093.1 YxeA family protein -
O4Z47_RS14535 (O4Z47_14535) 34476..34937 - 462 WP_269689316.1 hypothetical protein -
O4Z47_RS14540 (O4Z47_14540) 35709..36236 - 528 WP_269689317.1 replication initiation protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..55314 55314


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-104)

Antitoxin

Antitoxin PemI-like

(8-85)


Sequences

Toxin        


Download         Length: 115 a.a.        Molecular weight: 13041.89 Da        Isoelectric Point: 6.4782

>T266875 WP_001748110.1 NZ_CP114875:31858-32202 [Lactiplantibacillus plantarum]
MVSQGDIFYVNFNPSRGHEQMNKRPAIALSNDLVCQTSNMTIVAPISSTKRNFPMYHRLTSSQTVYGKVLLDQTIALDLR
ARHVTDETIVDHVSREELEEIITLYKLLFSIDDK

Download         Length: 345 bp

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 10141.51 Da        Isoelectric Point: 6.4708

>AT266875 WP_003643337.1 NZ_CP114875:31601-31864 [Lactiplantibacillus plantarum]
MELIKEQTRLAKWGNSKAARIPSQIIKQLKLDDNQDMTITIENGSIVLTPIKKNPTNIHELFKDWKDDGKRDHELDWGKS
EGNELQW

Download         Length: 264 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0R2K1X3

Antitoxin

Source ID Structure
AlphaFold DB A0A6L4ZZT2

References