266873

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) stbDE/ParE-YafN
Location 137115..137637 Replicon plasmid pS245-2
Accession NZ_CP114855
Organism Klebsiella pneumoniae strain S245

Toxin (Protein)


Gene name stbE Uniprot ID A0A7H0EVH6
Locus tag O5O52_RS27900 Protein ID WP_014839901.1
Coordinates 137115..137399 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name stbD Uniprot ID A0A7H0EVH5
Locus tag O5O52_RS27905 Protein ID WP_014839900.1
Coordinates 137389..137637 (-) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
O5O52_RS27865 (O5O52_27865) 132371..132580 + 210 WP_125316032.1 hypothetical protein -
O5O52_RS27870 (O5O52_27870) 132643..133587 + 945 WP_014839903.1 DsbA family protein -
O5O52_RS27875 (O5O52_27875) 133668..134189 + 522 WP_048336588.1 hypothetical protein -
O5O52_RS27880 (O5O52_27880) 134186..134788 + 603 WP_014839902.1 HAD domain-containing protein -
O5O52_RS27885 (O5O52_27885) 135029..135748 + 720 WP_042934502.1 cation:proton antiporter -
O5O52_RS27890 (O5O52_27890) 135765..136442 - 678 WP_042934501.1 hypothetical protein -
O5O52_RS27895 (O5O52_27895) 136448..136924 - 477 WP_042934526.1 hypothetical protein -
O5O52_RS27900 (O5O52_27900) 137115..137399 - 285 WP_014839901.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
O5O52_RS27905 (O5O52_27905) 137389..137637 - 249 WP_014839900.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
O5O52_RS27910 (O5O52_27910) 137978..139381 + 1404 WP_001567368.1 ISNCY-like element ISKpn21 family transposase -
O5O52_RS27915 (O5O52_27915) 139410..140042 - 633 WP_001567369.1 hypothetical protein -
O5O52_RS27920 (O5O52_27920) 140586..141194 - 609 WP_024266306.1 DUF2913 family protein -
O5O52_RS27925 (O5O52_27925) 141331..141729 - 399 WP_014839899.1 H-NS family nucleoid-associated regulatory protein -
O5O52_RS27930 (O5O52_27930) 142103..142459 - 357 WP_017901071.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid mph(A) / blaNDM-1 / sul1 / qacE / aadA16 / dfrA27 / ARR-3 / aac(6')-Ib-cr / qnrS1 / aph(3'')-Ib / sul2 / blaSFO-1 / msr(E) / mph(E) - 1..155225 155225
- flank IS/Tn - - 137978..139381 1403


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-83)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10866.46 Da        Isoelectric Point: 10.5831

>T266873 WP_014839901.1 NZ_CP114855:c137399-137115 [Klebsiella pneumoniae]
MTYKLAFNESALKEWKKLGHTIREQFKKKLSERLQNPRVPAAQLHGGKDQYKIKLHGAGYRLVYSVNDEIVTVTVIGVGK
RNNDDIYNATRHRN

Download         Length: 285 bp

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9071.29 Da        Isoelectric Point: 3.8832

>AT266873 WP_014839900.1 NZ_CP114855:c137637-137389 [Klebsiella pneumoniae]
MAFQVLTTTAASITELKRDPMGTFNAGEGAPVAILNRNEPAFYCVPPALYAQLMEMLEDQELGRIADERIGEDRIEVNID
DL

Download         Length: 249 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7H0EVH6

Antitoxin

Source ID Structure
AlphaFold DB A0A7H0EVH5

References