Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 5254708..5255333 Replicon chromosome
Accession NZ_CP114853
Organism Klebsiella pneumoniae strain S245

Toxin (Protein)


Gene name vapC Uniprot ID R4Y4A3
Locus tag O5O52_RS25475 Protein ID WP_002882817.1
Coordinates 5254708..5255091 (-) Length 128 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID J2DFR0
Locus tag O5O52_RS25480 Protein ID WP_004150355.1
Coordinates 5255091..5255333 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
O5O52_RS25460 (5252074) 5252074..5252976 + 903 WP_002882822.1 formate dehydrogenase subunit beta -
O5O52_RS25465 (5252973) 5252973..5253608 + 636 WP_002882818.1 formate dehydrogenase cytochrome b556 subunit -
O5O52_RS25470 (5253605) 5253605..5254534 + 930 WP_004150358.1 formate dehydrogenase accessory protein FdhE -
O5O52_RS25475 (5254708) 5254708..5255091 - 384 WP_002882817.1 type II toxin-antitoxin system VapC family toxin Toxin
O5O52_RS25480 (5255091) 5255091..5255333 - 243 WP_004150355.1 CopG family transcriptional regulator Antitoxin
O5O52_RS25485 (5255538) 5255538..5256455 + 918 WP_009484979.1 alpha/beta hydrolase -
O5O52_RS25490 (5256469) 5256469..5257410 - 942 WP_004178031.1 fatty acid biosynthesis protein FabY -
O5O52_RS25495 (5257455) 5257455..5257892 - 438 WP_002882809.1 D-aminoacyl-tRNA deacylase -
O5O52_RS25500 (5257889) 5257889..5258749 - 861 WP_004146232.1 virulence factor BrkB family protein -
O5O52_RS25505 (5258743) 5258743..5259342 - 600 WP_004151865.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-112)

Antitoxin

Predicted DNA-binding protein, ribbon-helix-helix domain

(16-47)


Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 14377.62 Da        Isoelectric Point: 7.3178

>T266871 WP_002882817.1 NZ_CP114853:c5255091-5254708 [Klebsiella pneumoniae]
MTSGSALFDTNILIDLFSGRREAKQALEAWPPQNAISLITWMEVMVGAKKYHQEQRTRMALSTFNIINISQDIAERSVAL
RQEYKLKLPDAIILATAQLHRLELITRNTKDFAGIPGVVTPYEIHPE

Download         Length: 384 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9567.83 Da        Isoelectric Point: 4.3509

>AT266871 WP_004150355.1 NZ_CP114853:c5255333-5255091 [Klebsiella pneumoniae]
MMAERDMGRILLDLSDDVIQRLDDLKVQRNIPRAELLREAVEQYLEKQDRAKDTISSALGLWQDCEEDGMEYQRQLRKEW

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GPK8

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GGU9

References