Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4770279..4770795 Replicon chromosome
Accession NZ_CP114853
Organism Klebsiella pneumoniae strain S245

Toxin (Protein)


Gene name relE Uniprot ID R4YAY3
Locus tag O5O52_RS23165 Protein ID WP_004178374.1
Coordinates 4770279..4770563 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A919M0P8
Locus tag O5O52_RS23170 Protein ID WP_032434351.1
Coordinates 4770553..4770795 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
O5O52_RS23140 (4765762) 4765762..4766025 - 264 WP_014908078.1 PTS sugar transporter subunit IIB -
O5O52_RS23145 (4766155) 4766155..4766328 + 174 WP_032414379.1 hypothetical protein -
O5O52_RS23150 (4766331) 4766331..4767074 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
O5O52_RS23155 (4767431) 4767431..4769569 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
O5O52_RS23160 (4769811) 4769811..4770275 + 465 WP_004222151.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
O5O52_RS23165 (4770279) 4770279..4770563 - 285 WP_004178374.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
O5O52_RS23170 (4770553) 4770553..4770795 - 243 WP_032434351.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
O5O52_RS23175 (4770873) 4770873..4772783 - 1911 WP_110138999.1 PRD domain-containing protein -
O5O52_RS23180 (4772806) 4772806..4773960 - 1155 WP_002886900.1 lactonase family protein -
O5O52_RS23185 (4774026) 4774026..4774766 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-68)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11155.97 Da        Isoelectric Point: 10.3787

>T266869 WP_004178374.1 NZ_CP114853:c4770563-4770279 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9003.47 Da        Isoelectric Point: 6.3340

>AT266869 WP_032434351.1 NZ_CP114853:c4770795-4770553 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGGKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A6THG1

Antitoxin

Source ID Structure

References