Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) ykfI-yfjZ/CbtA-CbeA
Location 4677551..4678254 Replicon chromosome
Accession NZ_CP114853
Organism Klebsiella pneumoniae strain S245

Toxin (Protein)


Gene name ykfI Uniprot ID A0A939NMR5
Locus tag O5O52_RS22770 Protein ID WP_071994632.1
Coordinates 4677551..4677892 (-) Length 114 a.a.

Antitoxin (Protein)


Gene name yfjZ Uniprot ID A0A939NIK9
Locus tag O5O52_RS22775 Protein ID WP_032434296.1
Coordinates 4677913..4678254 (-) Length 114 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
O5O52_RS22760 (4673866) 4673866..4674735 + 870 WP_023317468.1 HNH endonuclease -
O5O52_RS22765 (4675326) 4675326..4677359 + 2034 WP_050598589.1 hypothetical protein -
O5O52_RS22770 (4677551) 4677551..4677892 - 342 WP_071994632.1 TA system toxin CbtA family protein Toxin
O5O52_RS22775 (4677913) 4677913..4678254 - 342 WP_032434296.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
O5O52_RS22780 (4678265) 4678265..4678807 - 543 WP_032434298.1 DNA repair protein RadC -
O5O52_RS22785 (4678820) 4678820..4679260 - 441 WP_032434300.1 antirestriction protein -
O5O52_RS22790 (4679291) 4679291..4680112 - 822 WP_032434301.1 DUF932 domain-containing protein -
O5O52_RS22795 (4680232) 4680232..4680705 - 474 WP_032434303.1 hypothetical protein -
O5O52_RS22800 (4680777) 4680777..4681229 - 453 WP_032410767.1 hypothetical protein -
O5O52_RS22805 (4681265) 4681265..4681981 - 717 WP_032434305.1 WYL domain-containing protein -
O5O52_RS22810 (4682225) 4682225..4683099 - 875 Protein_4470 GTPase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 4665848..4711521 45673


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(13-112)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12789.77 Da        Isoelectric Point: 9.6552

>T266868 WP_071994632.1 NZ_CP114853:c4677892-4677551 [Klebsiella pneumoniae]
MKTLPATTPQAVTLCLSSVAVWQMLLARLLEQHYGLTLNDTPFSDETVIQEHIDAGISLADAVNFLVEKYGLVRIDRKGF
NWQEHSPYLRAVDILRARQATGLLRRSRKNAVR

Download         Length: 342 bp

Antitoxin


Download         Length: 114 a.a.        Molecular weight: 12893.40 Da        Isoelectric Point: 5.9612

>AT266868 WP_032434296.1 NZ_CP114853:c4678254-4677913 [Klebsiella pneumoniae]
MKSTDSENDSFLKWGLNRNVTPCFGARLVQEGNRLHYLADRASITGEFSNAESLKLDEVFPHFISQMESMLTTGEMNPRH
AHFFTLYHNGFTCEADTLGSYGYVYIAVYPTQR

Download         Length: 342 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References