Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2696177..2697765 Replicon chromosome
Accession NZ_CP114853
Organism Klebsiella pneumoniae strain S245

Toxin (Protein)


Gene name hipA Uniprot ID A0A9J6RYF8
Locus tag O5O52_RS13335 Protein ID WP_004892016.1
Coordinates 2696177..2697499 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag O5O52_RS13340 Protein ID WP_004176198.1
Coordinates 2697499..2697765 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
O5O52_RS13320 (2691233) 2691233..2693734 + 2502 WP_032435337.1 fimbria/pilus outer membrane usher protein -
O5O52_RS13325 (2693722) 2693722..2694726 + 1005 WP_032435338.1 fimbrial protein -
O5O52_RS13330 (2694868) 2694868..2696160 + 1293 WP_002904794.1 glycoside hydrolase family 10 protein -
O5O52_RS13335 (2696177) 2696177..2697499 - 1323 WP_004892016.1 type II toxin-antitoxin system HipA family toxin Toxin
O5O52_RS13340 (2697499) 2697499..2697765 - 267 WP_004176198.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
O5O52_RS13345 (2698152) 2698152..2698478 - 327 WP_004184023.1 hydroxyisourate hydrolase -
O5O52_RS13350 (2698475) 2698475..2698975 - 501 WP_032435339.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
O5O52_RS13355 (2698953) 2698953..2700332 - 1380 WP_004184021.1 nucleobase:cation symporter-2 family protein -
O5O52_RS13360 (2700678) 2700678..2701832 + 1155 WP_002904783.1 FAD-dependent urate hydroxylase HpxO -
O5O52_RS13365 (2701813) 2701813..2702736 - 924 WP_008804925.1 LysR family hpxDE operon transcriptional regulator HpxR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(149-402)

Antitoxin

Cro/C1-type helix-turn-helix domain

(13-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49141.44 Da        Isoelectric Point: 7.5357

>T266864 WP_004892016.1 NZ_CP114853:c2697499-2696177 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITGQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9936.36 Da        Isoelectric Point: 8.5912

>AT266864 WP_004176198.1 NZ_CP114853:c2697765-2697499 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMMLNAKAAETAPAP
DNNTDLDW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References