Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 793983..794640 Replicon chromosome
Accession NZ_CP114853
Organism Klebsiella pneumoniae strain S245

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag O5O52_RS03940 Protein ID WP_002916310.1
Coordinates 794230..794640 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag O5O52_RS03935 Protein ID WP_002916312.1
Coordinates 793983..794249 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
O5O52_RS03910 (789191) 789191..790624 - 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -
O5O52_RS03915 (790743) 790743..791471 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
O5O52_RS03920 (791521) 791521..791832 + 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
O5O52_RS03925 (791996) 791996..792655 + 660 WP_004174454.1 hemolysin III family protein -
O5O52_RS03930 (792754) 792754..793737 - 984 WP_023286864.1 tRNA-modifying protein YgfZ -
O5O52_RS03935 (793983) 793983..794249 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
O5O52_RS03940 (794230) 794230..794640 + 411 WP_002916310.1 protein YgfX Toxin
O5O52_RS03945 (794647) 794647..795168 - 522 WP_002916308.1 flavodoxin FldB -
O5O52_RS03950 (795269) 795269..796165 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
O5O52_RS03955 (796188) 796188..796901 + 714 WP_004174456.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
O5O52_RS03960 (796907) 796907..798640 + 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T266858 WP_002916310.1 NZ_CP114853:794230-794640 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT266858 WP_002916312.1 NZ_CP114853:793983-794249 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References