Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) shpAB/BrnT-BrnA
Location 4186308..4186884 Replicon chromosome
Accession NZ_CP114801
Organism Citrobacter sp. 21OH12SH02A-Citro

Toxin (Protein)


Gene name shpA Uniprot ID A0A8I0KMP7
Locus tag O6D90_RS20220 Protein ID WP_016155613.1
Coordinates 4186597..4186884 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name shpB Uniprot ID A0A2I8S1U6
Locus tag O6D90_RS20215 Protein ID WP_016155614.1
Coordinates 4186308..4186610 (-) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
O6D90_RS20200 (4182810) 4182810..4183004 + 195 WP_003830038.1 YbdD/YjiX family protein -
O6D90_RS20205 (4183017) 4183017..4183973 + 957 WP_016155616.1 GTPase -
O6D90_RS20210 (4184160) 4184160..4186007 + 1848 WP_016155615.1 3'-5' exonuclease -
O6D90_RS20215 (4186308) 4186308..4186610 - 303 WP_016155614.1 BrnA antitoxin family protein Antitoxin
O6D90_RS20220 (4186597) 4186597..4186884 - 288 WP_016155613.1 BrnT family toxin Toxin
O6D90_RS20225 (4187119) 4187119..4188285 + 1167 WP_019078303.1 restriction endonuclease -
O6D90_RS20230 (4188381) 4188381..4188527 + 147 Protein_3961 type I restriction endonuclease subunit R -
O6D90_RS20235 (4188514) 4188514..4188774 + 261 Protein_3962 endoribonuclease SymE -
O6D90_RS20240 (4188869) 4188869..4189360 - 492 WP_016151575.1 type VI secretion system tube protein TssD -
O6D90_RS20245 (4189599) 4189599..4189868 - 270 WP_271143192.1 hypothetical protein -
O6D90_RS20250 (4189868) 4189868..4190299 - 432 WP_225836832.1 DUF2778 domain-containing protein -
O6D90_RS20255 (4190457) 4190457..4190627 - 171 Protein_3966 hypothetical protein -
O6D90_RS20260 (4190633) 4190633..4191087 - 455 Protein_3967 MarR family transcriptional regulator -
O6D90_RS20265 (4191236) 4191236..4191400 - 165 WP_016155606.1 DUF1127 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(7-88)

Antitoxin

BrnA antitoxin of type II toxin-antitoxin system

(42-93)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11310.75 Da        Isoelectric Point: 7.4687

>T266851 WP_016155613.1 NZ_CP114801:c4186884-4186597 [Citrobacter sp. 21OH12SH02A-Citro]
MPMEFEWDANKAQSNLRKHGVRFEDAILVFDDPQHLSRQERYENGEYRWQTIGLVHGIVVILVAHSVRFESGFEVIRIIS
ARKADRKERNRYEHS

Download         Length: 288 bp

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11466.12 Da        Isoelectric Point: 10.1293

>AT266851 WP_016155614.1 NZ_CP114801:c4186610-4186308 [Citrobacter sp. 21OH12SH02A-Citro]
MSIVKHKRGSVSALSAQHEAELKALANKPDDDIDYSDIPVTEDKQWSEAIRGKFFRPLKTQASVRIDADVMEWLKRPGKG
YQTRLNAILREAMLREQNKK

Download         Length: 303 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A2I8S1U6

References