Detailed information of TA system TA026685

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tsbAT/-
• Location: 1853375..1854151
• Replicon: chromosome
• Accession: NC_017343
• Organism: Staphylococcus aureus subsp. aureus ECT-R 2

Toxin (Protein)

• Gene name: tsbT
• Uniprot ID: X5E2E6
• Locus tag: ECTR2_RS09040
• Protein ID: WP_000031108.1
• Coordinates: 1853375..1853527 (-)
• Length: 51 a.a.

Antitoxin (Protein)

• Gene name: tsbA
• Uniprot ID: W8U4V4
• Locus tag: ECTR2_RS09045
• Protein ID: WP_001251224.1
• Coordinates: 1853552..1854151 (-)
• Length: 200 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ECTR2_RS09025	1849577..1850398	+	822	WP_000669376.1	RluA family pseudouridine synthase	-
ECTR2_RS09030	1850851..1852236	-	1386	WP_000116228.1	class II fumarate hydratase	-
ECTR2_RS09035	1852432..1852827	-	396	WP_000901023.1	hypothetical protein	-
ECTR2_RS09040	1853375..1853527	-	153	WP_000031108.1	hypothetical protein	Toxin
ECTR2_RS09045	1853552..1854151	-	600	WP_001251224.1	glucosamine-6-phosphate isomerase	Antitoxin
ECTR2_RS09050	1854310..1854780	-	471	WP_000181394.1	tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL	-
ECTR2_RS09055	1854785..1855912	-	1128	WP_000379980.1	tRNA epoxyqueuosine(34) reductase QueG	-
ECTR2_RS09060	1856063..1856785	-	723	WP_000590809.1	amino acid ABC transporter ATP-binding protein	-
ECTR2_RS09065	1856778..1858235	-	1458	WP_000649912.1	ABC transporter permease subunit	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Glucosamine-6-phosphate isomerase (124-196)

Sequences

Toxin

Protein

• Length: 51 a.a.
• Molecular weight: 5936.28 Da
• Isoelectric Point: 3.8962

>T26685 WP_000031108.1 NC_017343:c1853527-1853375 [Staphylococcus aureus subsp. aureus ECT-R 2]
MSKDKDPKLNYHEEENSMVTDFEDLKELGKEMEQISDQNDQEKNSEEDSQ

Nucleotide

• Length: 153 bp

>T26685 NC_017343:c1853527-1853375 [Staphylococcus aureus subsp. aureus ECT-R 2]
ATGTCTAAAGACAAAGATCCAAAATTAAATTATCATGAAGAAGAAAACAGTATGGTAACGGATTTTGAAGATTTAAAAGA
ATTAGGTAAAGAAATGGAACAAATCTCTGATCAAAATGATCAAGAAAAAAATTCTGAAGAAGACAGTCAGTAA

Antitoxin

Protein

• Length: 200 a.a.
• Molecular weight: 22343.47 Da
• Isoelectric Point: 5.1445

>AT26685 WP_001251224.1 NC_017343:c1854151-1853552 [Staphylococcus aureus subsp. aureus ECT-R 2]
MAMNFKVFDNSQLVAEYAADIIRKQFNNNPTTIAGFHLDTDQAPVLDELKKNVEKHAVDFSQINILDYDDKKSYFEALGV
PAGQVYPIAYEKDAIELIADKIKTKENKGKLTLQVVSIDEQGKLNVSIRQGLMEAREIFLVVTGANKRDVVEKLYQENGK
TSFEPADLKAHRMVNVILDKEAAAGLPEDVKAYFTSRFA

Nucleotide

• Length: 600 bp

>AT26685 NC_017343:c1854151-1853552 [Staphylococcus aureus subsp. aureus ECT-R 2]
ATGGCAATGAACTTTAAAGTCTTTGACAATAGTCAACTTGTAGCAGAATATGCTGCTGATATTATTAGAAAGCAATTTAA
CAATAATCCTACTACAATTGCAGGTTTTCATTTAGATACAGATCAAGCGCCAGTTCTAGATGAATTAAAGAAAAATGTTG
AAAAACATGCTGTTGATTTTAGCCAAATAAATATTTTAGATTATGACGATAAAAAATCATATTTCGAAGCGTTAGGTGTA
CCAGCAGGTCAAGTTTATCCAATTGCTTATGAAAAAGATGCAATCGAATTAATCGCTGATAAGATTAAAACTAAAGAAAA
TAAAGGGAAATTAACATTACAAGTTGTTTCTATCGATGAGCAAGGTAAGTTAAATGTTAGTATTCGTCAAGGACTAATGG
AAGCAAGAGAAATTTTCTTAGTAGTGACAGGTGCTAATAAACGAGATGTAGTTGAAAAATTATATCAAGAAAATGGTAAA
ACAAGCTTCGAACCAGCCGATTTAAAAGCACATAGAATGGTAAATGTTATTCTTGATAAAGAAGCGGCTGCAGGTTTACC
TGAAGATGTTAAAGCTTACTTTACGTCACGCTTTGCTTAA

Structures

Toxin

• AlphaFold DB: X5E2E6

Antitoxin

• AlphaFold DB: W8U4V4