266849

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3603725..3604345 Replicon chromosome
Accession NZ_CP114801
Organism Citrobacter sp. 21OH12SH02A-Citro

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag O6D90_RS17620 Protein ID WP_002892050.1
Coordinates 3604127..3604345 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID R8WZW8
Locus tag O6D90_RS17615 Protein ID WP_003021733.1
Coordinates 3603725..3604099 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
O6D90_RS17605 (3598872) 3598872..3600065 + 1194 WP_016152074.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
O6D90_RS17610 (3600088) 3600088..3603237 + 3150 WP_016152073.1 efflux RND transporter permease AcrB -
O6D90_RS17615 (3603725) 3603725..3604099 + 375 WP_003021733.1 Hha toxicity modulator TomB Antitoxin
O6D90_RS17620 (3604127) 3604127..3604345 + 219 WP_002892050.1 HHA domain-containing protein Toxin
O6D90_RS17625 (3604526) 3604526..3605077 + 552 WP_016155874.1 maltose O-acetyltransferase -
O6D90_RS17630 (3605194) 3605194..3605664 + 471 WP_016152071.1 YlaC family protein -
O6D90_RS17635 (3605743) 3605743..3605883 - 141 WP_005125190.1 type B 50S ribosomal protein L36 -
O6D90_RS17640 (3605885) 3605885..3606145 - 261 WP_016152070.1 type B 50S ribosomal protein L31 -
O6D90_RS17645 (3606334) 3606334..3607887 + 1554 WP_016155873.1 EAL domain-containing protein -
O6D90_RS17650 (3607939) 3607939..3608292 - 354 WP_003831033.1 DUF1428 family protein -
O6D90_RS17655 (3608357) 3608357..3608986 - 630 WP_016155872.1 membrane protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T266849 WP_002892050.1 NZ_CP114801:3604127-3604345 [Citrobacter sp. 21OH12SH02A-Citro]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14427.23 Da        Isoelectric Point: 5.5653

>AT266849 WP_003021733.1 NZ_CP114801:3603725-3604099 [Citrobacter sp. 21OH12SH02A-Citro]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEQSNHGWVNDPTSATSLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB R8WZW8

References