Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 851538..852192 Replicon chromosome
Accession NZ_CP114801
Organism Citrobacter sp. 21OH12SH02A-Citro

Toxin (Protein)


Gene name cptA Uniprot ID R8WN60
Locus tag O6D90_RS04195 Protein ID WP_016154348.1
Coordinates 851785..852192 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID R8WMJ6
Locus tag O6D90_RS04190 Protein ID WP_016154349.1
Coordinates 851538..851804 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
O6D90_RS04165 (846751) 846751..848184 - 1434 WP_016154353.1 6-phospho-beta-glucosidase BglA -
O6D90_RS04170 (848305) 848305..849033 - 729 WP_003838265.1 MurR/RpiR family transcriptional regulator -
O6D90_RS04175 (849086) 849086..849397 + 312 WP_016154352.1 N(4)-acetylcytidine aminohydrolase -
O6D90_RS04180 (849561) 849561..850220 + 660 WP_016154351.1 hemolysin III family protein -
O6D90_RS04185 (850300) 850300..851280 - 981 WP_016157415.1 tRNA-modifying protein YgfZ -
O6D90_RS04190 (851538) 851538..851804 + 267 WP_016154349.1 FAD assembly factor SdhE Antitoxin
O6D90_RS04195 (851785) 851785..852192 + 408 WP_016154348.1 protein YgfX Toxin
O6D90_RS04200 (852293) 852293..852814 - 522 WP_016157414.1 flavodoxin FldB -
O6D90_RS04205 (852928) 852928..853824 + 897 WP_016154346.1 site-specific tyrosine recombinase XerD -
O6D90_RS04210 (853848) 853848..854561 + 714 WP_016154345.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
O6D90_RS04215 (854567) 854567..856300 + 1734 WP_016157413.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 15850.66 Da        Isoelectric Point: 11.2845

>T266843 WP_016154348.1 NZ_CP114801:851785-852192 [Citrobacter sp. 21OH12SH02A-Citro]
VVQWQSDLRVSWRAQWLSLLIHGLVAVFILLMPWPLSYTPLWLVLLSLVVFDSVRSQRRINACQGEIRLLMDGRLRWQGQ
EWTIASAPWMVKTGMMLRLRSDAGKRQHLWLAADSMDDAEWRDLRRLILQQAKQG

Download         Length: 408 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10557.10 Da        Isoelectric Point: 5.6375

>AT266843 WP_016154349.1 NZ_CP114801:851538-851804 [Citrobacter sp. 21OH12SH02A-Citro]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDEEKRIFIRLLECDDPDLFNWLMNHGKPADAQLEQMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB R8WN60

Antitoxin

Source ID Structure
AlphaFold DB R8WMJ6

References