Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907-MazE
Location 29260..29837 Replicon plasmid p21OH12SH02B-2
Accession NZ_CP114798
Organism Providencia sp. 21OH12SH02B-Prov

Toxin (Protein)


Gene name mazF Uniprot ID U5N651
Locus tag O7C57_RS21175 Protein ID WP_023159957.1
Coordinates 29260..29592 (-) Length 111 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag O7C57_RS21180 Protein ID WP_096864992.1
Coordinates 29592..29837 (-) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
O7C57_RS21150 (O7C57_21150) 25270..26085 - 816 WP_269724013.1 DUF4365 domain-containing protein -
O7C57_RS21155 (O7C57_21155) 26101..27054 - 954 WP_269724014.1 site-specific integrase -
O7C57_RS21160 (O7C57_21160) 27458..28255 + 798 WP_048607643.1 hypothetical protein -
O7C57_RS21165 (O7C57_21165) 28620..28763 + 144 WP_071547955.1 Hok/Gef family protein -
O7C57_RS21170 (O7C57_21170) 28849..29229 - 381 WP_096864991.1 hypothetical protein -
O7C57_RS21175 (O7C57_21175) 29260..29592 - 333 WP_023159957.1 endoribonuclease MazF Toxin
O7C57_RS21180 (O7C57_21180) 29592..29837 - 246 WP_096864992.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
O7C57_RS21185 (O7C57_21185) 30107..30730 + 624 WP_109910889.1 AAA family ATPase -
O7C57_RS21190 (O7C57_21190) 30831..31058 + 228 WP_096864993.1 plasmid partition protein ParG -
O7C57_RS21195 (O7C57_21195) 31156..31524 - 369 WP_109910890.1 hypothetical protein -
O7C57_RS21200 (O7C57_21200) 31757..32266 - 510 WP_282559889.1 hypothetical protein -
O7C57_RS21205 (O7C57_21205) 32276..32698 - 423 WP_048821775.1 hypothetical protein -
O7C57_RS21210 (O7C57_21210) 32691..33035 - 345 WP_023159966.1 single-stranded DNA-binding protein -
O7C57_RS21215 (O7C57_21215) 33038..34084 - 1047 WP_072070749.1 ParB/RepB/Spo0J family partition protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..43629 43629


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(9-107)

Antitoxin

SpoVT-AbrB domain

(7-49)


Sequences

Toxin        


Download         Length: 111 a.a.        Molecular weight: 12097.88 Da        Isoelectric Point: 7.0813

>T266841 WP_023159957.1 NZ_CP114798:c29592-29260 [Providencia sp. 21OH12SH02B-Prov]
MVSRYVPDSGDLIWIDFDPVEGHEQGGHRPAVVLSPFAYNNKVGLLLCVPCTTKGKGYPFECELSNERDSYALADQVTCV
DWRARKVTKKGKVEASELAEIKAKAKALIG

Download         Length: 333 bp

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 8800.23 Da        Isoelectric Point: 5.0508

>AT266841 WP_096864992.1 NZ_CP114798:c29837-29592 [Providencia sp. 21OH12SH02B-Prov]
MAQVTVKKWGNSPSVRLPVAIMQKAALSVDDTVEIAVEEGRIIITPVKAVEYSLENLLAGITPENIHEKVDFGARTGKEL
I

Download         Length: 246 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P1BQ75

Antitoxin

Source ID Structure

References