Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3553370..3554020 Replicon chromosome
Accession NZ_CP114796
Organism Providencia sp. 21OH12SH02B-Prov

Toxin (Protein)


Gene name Hha Uniprot ID K8W3H1
Locus tag O7C57_RS16515 Protein ID WP_004927064.1
Coordinates 3553817..3554020 (+) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID -
Locus tag O7C57_RS16510 Protein ID WP_154635730.1
Coordinates 3553370..3553738 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
O7C57_RS16485 (O7C57_16485) 3548513..3549274 - 762 WP_269723356.1 DNA polymerase III subunit epsilon -
O7C57_RS16490 (O7C57_16490) 3549329..3549799 + 471 WP_154624044.1 ribonuclease HI -
O7C57_RS16495 (O7C57_16495) 3549866..3550591 - 726 WP_154624043.1 methyltransferase domain-containing protein -
O7C57_RS16500 (O7C57_16500) 3550631..3551386 + 756 WP_269723357.1 hydroxyacylglutathione hydrolase -
O7C57_RS16505 (O7C57_16505) 3551465..3552802 + 1338 WP_154624041.1 murein transglycosylase D -
O7C57_RS16510 (O7C57_16510) 3553370..3553738 + 369 WP_154635730.1 Hha toxicity modulator TomB Antitoxin
O7C57_RS16515 (O7C57_16515) 3553817..3554020 + 204 WP_004927064.1 HHA domain-containing protein Toxin
O7C57_RS16525 (O7C57_16525) 3554630..3555088 - 459 WP_196713815.1 YbaY family lipoprotein -
O7C57_RS16530 (O7C57_16530) 3555413..3556279 + 867 WP_154622395.1 acyl-CoA thioesterase II -
O7C57_RS16535 (O7C57_16535) 3556507..3557790 - 1284 WP_154622396.1 ammonium transporter AmtB -
O7C57_RS16540 (O7C57_16540) 3557801..3558139 - 339 WP_154622397.1 P-II family nitrogen regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8075.37 Da        Isoelectric Point: 6.9770

>T266840 WP_004927064.1 NZ_CP114796:3553817-3554020 [Providencia sp. 21OH12SH02B-Prov]
MTKTDYLMRLRKCTTIDTLERVIEKNKYELSEDELELFYSAADHRLAELTMNKLYDKIPASVWKFVR

Download         Length: 204 bp

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14106.92 Da        Isoelectric Point: 4.3486

>AT266840 WP_154635730.1 NZ_CP114796:3553370-3553738 [Providencia sp. 21OH12SH02B-Prov]
MDEYSPKNYDISELKYLCNSLNREAISSLQKTNTHWINDLSSPQSVRLNELIEHIAAFVWQYKIKHPKDNLVISLVEEYL
DETYDLFGSPVITLSEIIDWQSMNQNLVAVLDDDLKCPASKT

Download         Length: 369 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB K8W3H1

Antitoxin

Source ID Structure

References