266831

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 68812..69548 Replicon plasmid p3045-2
Accession NZ_CP114774
Organism Raoultella planticola strain RP_3045

Toxin (Protein)


Gene name tacT Uniprot ID L7SZ15
Locus tag O4J57_RS28945 Protein ID WP_003026803.1
Coordinates 68812..69294 (-) Length 161 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID L7SZ29
Locus tag O4J57_RS28950 Protein ID WP_003026799.1
Coordinates 69282..69548 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
O4J57_RS28925 (O4J57_28920) 64679..64810 - 132 WP_004218042.1 hypothetical protein -
O4J57_RS28930 (O4J57_28925) 64971..66317 - 1347 WP_020314316.1 ISNCY family transposase -
O4J57_RS28935 (O4J57_28930) 66547..67179 + 633 WP_001567369.1 hypothetical protein -
O4J57_RS28940 (O4J57_28935) 67208..68611 - 1404 WP_001567368.1 ISNCY-like element ISKpn21 family transposase -
O4J57_RS28945 (O4J57_28940) 68812..69294 - 483 WP_003026803.1 GNAT family N-acetyltransferase Toxin
O4J57_RS28950 (O4J57_28945) 69282..69548 - 267 WP_003026799.1 DUF1778 domain-containing protein Antitoxin
O4J57_RS28955 (O4J57_28950) 69818..70606 + 789 WP_077255422.1 hypothetical protein -
O4J57_RS28960 (O4J57_28955) 70552..71256 - 705 WP_001067855.1 IS6-like element IS26 family transposase -
O4J57_RS28965 (O4J57_28960) 71330..71596 + 267 WP_102047566.1 ArsA-related P-loop ATPase -
O4J57_RS28970 (O4J57_28965) 71627..72052 - 426 WP_000065758.1 glutaredoxin-dependent arsenate reductase -
O4J57_RS28975 (O4J57_28970) 72065..73354 - 1290 WP_000922630.1 arsenite efflux transporter membrane subunit ArsB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - - 1..212569 212569
- inside IScluster/Tn - - 62622..71256 8634


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(45-149)

Antitoxin

Vibrio phage ICP1, Orf50

(6-82)


Sequences

Toxin        


Download         Length: 161 a.a.        Molecular weight: 17353.97 Da        Isoelectric Point: 9.5822

>T266831 WP_003026803.1 NZ_CP114774:c69294-68812 [Raoultella planticola]
VGRITTPEPLSSSHQLAEFVSGETVLDEWLKQRGLKNQALGAARTFVVCKTGTKQVAGFYSLATGSVNHTEATGSLRRNM
PDPIPVIILARLAVDVSLHGKGVGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKGFYAHHGFKASQTHERTLFLKLP

Download         Length: 483 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10147.59 Da        Isoelectric Point: 4.5256

>AT266831 WP_003026799.1 NZ_CP114774:c69548-69282 [Raoultella planticola]
MKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACKAAENVILDRRVFNFNDEQYAEFIDMLDAPVEDEPAINKLL
ARKPQWDV

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0J2GNW6

Antitoxin

Source ID Structure
AlphaFold DB A0A1Q8YL66

References