266827

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2915900..2917503 Replicon chromosome
Accession NZ_CP114772
Organism Raoultella planticola strain RP_3045

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag O4J57_RS13990 Protein ID WP_046852509.1
Coordinates 2915900..2917231 (-) Length 444 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A2X2EM10
Locus tag O4J57_RS13995 Protein ID WP_032696205.1
Coordinates 2917231..2917503 (-) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
O4J57_RS13975 (O4J57_13975) 2911776..2912690 - 915 WP_015584333.1 branched-chain amino acid ABC transporter permease -
O4J57_RS13980 (O4J57_13980) 2912790..2913848 - 1059 WP_162180097.1 branched-chain amino acid ABC transporter substrate-binding protein -
O4J57_RS13985 (O4J57_13985) 2914561..2915967 + 1407 WP_032699891.1 glycoside hydrolase family 10 protein -
O4J57_RS13990 (O4J57_13990) 2915900..2917231 - 1332 WP_046852509.1 type II toxin-antitoxin system HipA family toxin Toxin
O4J57_RS13995 (O4J57_13995) 2917231..2917503 - 273 WP_032696205.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
O4J57_RS14000 (O4J57_14000) 2917697..2918251 - 555 WP_064793779.1 RNA polymerase sigma factor -
O4J57_RS14005 (O4J57_14005) 2918257..2918682 - 426 WP_032687741.1 hypothetical protein -
O4J57_RS14010 (O4J57_14010) 2918814..2919767 - 954 WP_032687742.1 hypothetical protein -
O4J57_RS14015 (O4J57_14015) 2919983..2920615 - 633 WP_064793778.1 class I SAM-dependent methyltransferase -
O4J57_RS14020 (O4J57_14020) 2920635..2921876 - 1242 WP_046852512.1 sensor domain-containing diguanylate cyclase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(4-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-69)


Sequences

Toxin        


Download         Length: 444 a.a.        Molecular weight: 49383.68 Da        Isoelectric Point: 6.5066

>T266827 WP_046852509.1 NZ_CP114772:c2917231-2915900 [Raoultella planticola]
MATLVTWMNNERVGELIKQANGAHLFRYEEAWMRNPRARPLSLSLPLQYGNITDDAVFNYFDNLLPDSPRVRDRIVKRYQ
ARSKQPFDLLAEIGRDSVGAVTLLPPGENATRGALSWEALDSHALDALLTAYQSDIPLGMVNEHDDFRISVAGAQEKTAL
LKIGEQWCIPTGTTPTTHIIKLPIGEIKQPDAVLDLSESVDNEYLCLALARALGFAVPRASIIQTASIRALAVERFDRRW
AQEKTVLLRLPQEDLCQAFGIPSSIKYESDGGPGIRAIMAFLVGSSEALEDRYNFMKFMVFQWLIGATDGHAKNFSIFLQ
PGGSYRLTPFYDIISAFPLLGGKGLHLSDLRLSMSLKASKGRKTEIQTLYPRHFLATAKEVGFAEEQMLEILRYFVDNVP
HAVAAVKETLPHDFSPPVYEAITDRLLWVHSRLQNAMAALPSG

Download         Length: 1332 bp

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 10168.43 Da        Isoelectric Point: 4.9491

>AT266827 WP_032696205.1 NZ_CP114772:c2917503-2917231 [Raoultella planticola]
MSPSPGIYSPVQLANYLKLVRQKNQWTQSDLAQRMGIKQATVSNFENHPEKTTLTTVFKILQSLELSMAICEKNAPDTND
SSDNPQDLDW

Download         Length: 273 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A2X2EM10

References